Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients
Joint Authors
Cyrus, Cyril
Vatte, Chittibabu
Borgio, J. Francis
Chathoth, Shahanas
Alrubaish, Nafie
Almuhanna, Othman
Al-Mueilo, Samir
Al Muhanna, Fahd
Al Ali, Amein K.
Source
International Journal of Nephrology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
End-stage renal disease (ESRD) is the result of hypertensive nephrosclerosis and chronic glomerular diseases and is associated with high morbidity and mortality.
There are strong heritable components in the manifestation of the disease with a genetic predisposition to renal disorders, including focal segmental glomerulosclerosis and arterionephrosclerosis.
Recent studies in genetics have examined modifiable risk factors that contribute to renal disease, and this has provided a deep insight into progressive kidney disease.
Single-nucleotide polymorphisms at the proximity of SHROOM3, CST3, SLC7A9, and MYH9 genes have been associated with an increased risk of developing CKD and ESRD.
Methods.
A total of 160 CKD patients and 189 control subjects of Saudi origin participated in the study.
Eight polymorphisms (SHROOM3-rs9992101, rs17319721; SLC7A9-rs4805834; MYH9-rs4821480, rs4821481, rs2032487, rs3752462; CST3-rs13038305) were genotyped using TaqMan assay, and the haplotype analysis was done using the HaploView 4.2 software.
Results.
Haplotype analysis revealed a novel haplotype “E6”-GTTT to be associated significantly with an increased risk for ESRD (p=0.0001) and CKD (p=0.03).
Conclusion.
CKD is often silent until symptomatic uremia during the advanced stages of the disease.
The newly identified haplotype will help recognize patients at risk for a rapid progression of CKD to ESRD.
Accurate detection and mapping of the genetic variants facilitates improved risk stratification and development of improved and targeted therapeutic management for CKD.
American Psychological Association (APA)
Cyrus, Cyril& Chathoth, Shahanas& Vatte, Chittibabu& Alrubaish, Nafie& Almuhanna, Othman& Borgio, J. Francis…[et al.]. 2019. Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients. International Journal of Nephrology،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1166452
Modern Language Association (MLA)
Cyrus, Cyril…[et al.]. Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients. International Journal of Nephrology No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1166452
American Medical Association (AMA)
Cyrus, Cyril& Chathoth, Shahanas& Vatte, Chittibabu& Alrubaish, Nafie& Almuhanna, Othman& Borgio, J. Francis…[et al.]. Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients. International Journal of Nephrology. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1166452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166452