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Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion
Joint Authors
Emich-Widera, Ewa
Paprocka, Justyna
Pęcka, Marcin
Sokół, Maria
Kijonka, Marek
Wojcieszek, Piotr
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The main aim of the study was to compare the melatonin rhythms in subjects with Angelman syndrome (n=9) and in children with (n=80) and without (n=40) epilepsy (nonepileptic patients diagnosed with peripheral nerve palsies, myopathy, and back pain) using our mathematical model of melatonin circadian secretion.
The characteristics describing the diurnal hormone secretion such as minimum melatonin concentration, release amplitude, phase shift of melatonin release, and sleep duration as well as the dim light melatonin onset (DLMO) of melatonin secretion and the γ shape parameter allow analyzing the fit and deducing about how much the measured melatonin profile differs from a physiological bell-shaped secretion.
The estimated sleep duration and phase shift of melatonin release as well as the DMLO offsets at 25% and 50% relative thresholds are the key characteristic of Angelman syndrome children.
As revealed from the γ shape parameter, the melatonin secretion profiles are disturbed in majority of the AG subjects revealing rather a triangular course instead of the bell-like one.
American Psychological Association (APA)
Paprocka, Justyna& Kijonka, Marek& Wojcieszek, Piotr& Pęcka, Marcin& Emich-Widera, Ewa& Sokół, Maria. 2017. Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1166455
Modern Language Association (MLA)
Paprocka, Justyna…[et al.]. Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion. International Journal of Endocrinology No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1166455
American Medical Association (AMA)
Paprocka, Justyna& Kijonka, Marek& Wojcieszek, Piotr& Pęcka, Marcin& Emich-Widera, Ewa& Sokół, Maria. Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1166455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166455