Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome
Author
Source
International Journal of Nephrology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
As water and solutes are filtered through the slit membrane, it is an a priori concept that a slit membrane is an essential filtration barrier for proteins, including albumin.
However, in cases of minimal change nephrotic syndrome, the number of slit membranes is reduced by the foot process effacement and tight junction-like cell adhesion.
Furthermore, albumin endocytosis is enhanced in the podocytes under condition of minimal change disease, and albumin is selectively transported by the albumin receptor FcRn.
Suppressing the endocytosis of albumin with anti-FcRn antibody decreases the urinary protein level.
The expression of motor molecules, such as cytoplasmic dynein 1 and myosin IX, is increased in the podocytes under conditions of minimal change nephrotic syndrome, suggesting the enhanced transport of vesicles containing albumin.
Podocyte vesicle transport may play an important role in the pathology of selective albuminuria in cases of nephrotic syndrome.
American Psychological Association (APA)
Tojo, Akihiro. 2019. Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome. International Journal of Nephrology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166497
Modern Language Association (MLA)
Tojo, Akihiro. Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome. International Journal of Nephrology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1166497
American Medical Association (AMA)
Tojo, Akihiro. Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome. International Journal of Nephrology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1166497
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166497