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Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children
Joint Authors
Zhao, Xiaoyuan
Wu, Lijun
Zhang, Mei-Xian
Wu, Jianxin
Gao, Liwang
Mi, Jie
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (MC4R) gene and rs6265 near the brain-derived neurotrophic factor (BDNF) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children.
The aim of the present study is to investigate the associations between the SNPs and adiponectin that has a regulatory role in glucose and lipid metabolism.
Methods.
We examined the associations of the SNPs with adiponectin in Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study.
A total of 3503 children participated in the study.
Results.
The SNP rs6265 was significantly associated with adiponectin under an additive model (P=0.02 and 0.024, resp.) after adjustment for age, gender, and BMI or obesity statuses.
The SNP rs17782313 was significantly associated with low adiponectin under a recessive model.
No statistical significance was found between the two SNPs and low adiponectin after correction for multiple testing.
Conclusion.
We demonstrate for the first time that the SNP rs17782313 near MC4R and the SNP rs6265 near BDNF are associated with adiponectin in Chinese children.
These novel findings provide important evidence that adiponectin possibly mediates MC4R and BDNF involved in obesity.
American Psychological Association (APA)
Wu, Lijun& Gao, Liwang& Zhao, Xiaoyuan& Zhang, Mei-Xian& Wu, Jianxin& Mi, Jie. 2017. Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1166515
Modern Language Association (MLA)
Wu, Lijun…[et al.]. Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children. International Journal of Endocrinology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1166515
American Medical Association (AMA)
Wu, Lijun& Gao, Liwang& Zhao, Xiaoyuan& Zhang, Mei-Xian& Wu, Jianxin& Mi, Jie. Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1166515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166515