![](/images/graphics-bg.png)
Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment
Joint Authors
Wang, Yen-Ling
Fu, Shin-Huei
Hsu, Brend Ray-Sea
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to investigate whether tolerance-induced protection of islets in the renal subcapsular space can also prevent subcutaneous allogeneic islets from being rejected.
We used bone marrow stem cells from C57BL/6 (H2b) mice to construct donor chimerism in conditioned diabetic BALB/c (H2d) mice and investigated the effect of donor chimerism on engraftment and survival of subcutaneously transplanted allogeneic islets in streptozotocin-induced diabetic mice.
We also studied the anti-inflammatory effect of mesenchymal stem cell on islet engraftment.
Full but not low-grade or no donor chimerism was associated with successful engraftment of allogeneic islets and restoration of normoglycemia in the treated diabetic mice.
The temporary hyperglycemia was 11 ± 1 versus 19 ± 5 days (p<0.05) for the mice with full donor chimerism with transplanted islets in the renal subcapsular space versus the subcutaneous space, respectively.
Cotransplantation of mesenchymal stem cell did not enhance alloislet engraftment.
Full multilineage donor chimerism was associated with a higher transient expansion of CD11b+ and Gr-1+ myeloid progenitor cells and effector memory CD4 and CD8 T cells.
In conclusion, full donor chimerism protected both renal subcapsular and subcutaneous allogeneic islets in this rodent transplantation model.
American Psychological Association (APA)
Hsu, Brend Ray-Sea& Fu, Shin-Huei& Wang, Yen-Ling. 2017. Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166538
Modern Language Association (MLA)
Hsu, Brend Ray-Sea…[et al.]. Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166538
American Medical Association (AMA)
Hsu, Brend Ray-Sea& Fu, Shin-Huei& Wang, Yen-Ling. Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166538