Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly
Joint Authors
Bocharova, Anna
Vagaytseva, Kseniya
Stepanov, Vadim
Marusin, Andrey
Markova, Valentina
Minaycheva, Larisa
Makeeva, Oksana
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cognitive performance is an important endophenotype for various neurodegenerative and neuropsychiatric traits.
In the present study two genetic variants in the leucine-zipper protein (LUZP2) and the F-box 40 protein (FBXO40) genes, previously reported to be genome-wide significant for Alzheimer’s diseases and schizophrenia, were examined for an association with cognitive abilities in normal elderly from the Russian population.
Rs1021261 in the LUZP2 and rs3772130 in the FBXO40 were genotyped by multiplex PCR and MALDI-TOF mass spectrometry in a sample of 708 normal elderly subjects tested for cognitive performance using the Montreal Cognitive Assessment (MoCA).
Association of genetic variability with the MoCA scores was estimated by parametric and nonparametric analysis of variance and by the frequency comparison between upper and lower quartiles of MoCA distribution.
Significantly higher frequency of “TT” genotype of rs1021261 in the LUZP2 gene as well as “A” allele and “AA” genotype of rs3772130 in the FBXO40 gene was found in a subsample of individuals with the MoCA score less than 20 comparing to the fourth quartile’s subsample (MoCA > 25).
The data of the present study suggests that genetic variability in the LUZP2 and FBXO40 loci associated with neurodegenerative and neuropsychiatric diseases is also contributed to the normal variability in cognitive performance in the elderly.
American Psychological Association (APA)
Stepanov, Vadim& Vagaytseva, Kseniya& Bocharova, Anna& Marusin, Andrey& Markova, Valentina& Minaycheva, Larisa…[et al.]. 2018. Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly. International Journal of Alzheimer's Disease،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1166576
Modern Language Association (MLA)
Stepanov, Vadim…[et al.]. Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly. International Journal of Alzheimer's Disease No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1166576
American Medical Association (AMA)
Stepanov, Vadim& Vagaytseva, Kseniya& Bocharova, Anna& Marusin, Andrey& Markova, Valentina& Minaycheva, Larisa…[et al.]. Analysis of Association of Genetic Markers in the LUZP2 and FBXO40 Genes with the Normal Variability in Cognitive Performance in the Elderly. International Journal of Alzheimer's Disease. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1166576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166576