The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease
Joint Authors
Ismail, Rola
Hansen, Allan K.
Parbo, Peter
Brændgaard, Hans
Gottrup, Hanne
Brooks, David J.
Borghammer, Per
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder.
AD pathology is characterized by abnormal aggregation of the proteins amyloid-β (Aβ) and hyperphosphorylated tau.
No effective disease modifying therapies are currently available.
A short-duration intervention with 40 Hz light flicker has been shown to reduce brain Aβ load in transgenic mice.
We aimed to test the effect of a similar short-duration 40 Hz light flicker regime in human AD patients.
We utilized a Light Emitting Diode (LED) light bulb with a 40 Hz flicker.
Six Aβ positive patients received 10 days of light therapy, had 2 hours of daily exposure, and underwent a postintervention PiB PET on day 11.
After 10 days of light therapy, no significant decrease of PiB SUVR values was detected in any volumes of interest tested (primary visual cortex, visual association cortex, lateral parietal cortex, precuneus, and posterior cingulate) or in the total motor cortex, and longer treatments may be necessary to induce amyloid removal in humans.
American Psychological Association (APA)
Ismail, Rola& Hansen, Allan K.& Parbo, Peter& Brændgaard, Hans& Gottrup, Hanne& Brooks, David J.…[et al.]. 2018. The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1166584
Modern Language Association (MLA)
Ismail, Rola…[et al.]. The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1166584
American Medical Association (AMA)
Ismail, Rola& Hansen, Allan K.& Parbo, Peter& Brændgaard, Hans& Gottrup, Hanne& Brooks, David J.…[et al.]. The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1166584
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166584