Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes
Joint Authors
Weinberg, Robert P.
Koledova, Vera V.
Shin, Hyeari
Park, Jennifer H.
Tan, Yew Ai
Sinskey, Anthony J.
Sambanthamurthi, Ravigadevi
Rha, ChoKyun
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Alzheimer’s disease is a severe neurodegenerative disease characterized by the aggregation of amyloid-β peptide (Aβ) into toxic oligomers which activate microglia and astrocytes causing acute neuroinflammation.
Multiple studies show that the soluble oligomers of Aβ42 are neurotoxic and proinflammatory, whereas the monomers and insoluble fibrils are relatively nontoxic.
We show that Aβ42 aggregation is inhibited in vitro by oil palm phenolics (OPP), an aqueous extract from the oil palm tree (Elaeis guineensis).
The data shows that OPP inhibits stacking of β-pleated sheets, which is essential for oligomerization.
We demonstrate the inhibition of Aβ42 aggregation by (1) mass spectrometry; (2) Congo Red dye binding; (3) 2D-IR spectroscopy; (4) dynamic light scattering; (5) transmission electron microscopy; and (6) transgenic yeast rescue assay.
In the yeast rescue assay, OPP significantly reduces the cytotoxicity of aggregating neuropeptides in yeast genetically engineered to overexpress these peptides.
The data shows that OPP inhibits (1) the aggregation of Aβ into oligomers; (2) stacking of β-pleated sheets; and (3) fibrillar growth and coalescence.
These inhibitory effects prevent the formation of neurotoxic oligomers and hold potential as a means to reduce neuroinflammation and neuronal death and thereby may play some role in the prevention or treatment of Alzheimer’s disease.
American Psychological Association (APA)
Weinberg, Robert P.& Koledova, Vera V.& Shin, Hyeari& Park, Jennifer H.& Tan, Yew Ai& Sinskey, Anthony J.…[et al.]. 2018. Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes. International Journal of Alzheimer's Disease،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1166587
Modern Language Association (MLA)
Weinberg, Robert P.…[et al.]. Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes. International Journal of Alzheimer's Disease No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1166587
American Medical Association (AMA)
Weinberg, Robert P.& Koledova, Vera V.& Shin, Hyeari& Park, Jennifer H.& Tan, Yew Ai& Sinskey, Anthony J.…[et al.]. Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes. International Journal of Alzheimer's Disease. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1166587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166587