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Empagliflozin Increases Short-Term Urinary Volume Output in Artificially Induced Syndrome of Inappropriate Antidiuresis
Joint Authors
Refardt, Julie
Winzeler, Bettina
Meienberg, Fabian
Vogt, Deborah R.
Christ-Crain, Mirjam
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Syndrome of inappropriate antidiuresis (SIADH) is the predominant cause of hyponatremia, but treatment options are unsatisfying.
SGLT2 inhibitors increase urinary glucose excretion with concomitant osmotic diuresis.
We therefore hypothesized SGLT2-inhibitors as a novel treatment for SIADH.
Design.
Double-blind placebo-controlled randomised crossover study in 14 healthy volunteers.
Methods.
We induced an artificial SIADH model by administration of desmopressin and overhydration.
Afterwards, empagliflozin 25 mg or placebo was given in random order.
The main outcomes were total urinary excretion, glucosuria, and the area under the curve (AUC) of serum sodium concentration.
Outcome measures were obtained 2–8 hours after administration of study drug.
Results.
14 participants (64% males), BMI 23 kg/m2 (±2.4), aged 28.6 years (±9), completed the study.
Empagliflozin led to significantly increased total urinary excretion (579.3 ml (±194.8) versus 367.3 ml (±158.8); treatment effect 158 ml (CI 48.29, 267.74), p=0.017) due to glucosuria (74.18 mmol (±22.3) versus 0.12 mmol (±0.04); treatment effect (log scale) 2.85 (CI 2.75, 2.96), p<0.001).
There was no difference in the AUC of serum sodium concentration (treatment effect 0.2 (CI −7.38, 6.98), p=0.96).
Conclusion.
In our SIADH model, empagliflozin increased urinary excretion due to osmotic diuresis.
Due to the short treatment duration, serum sodium levels remained unchanged.
Real-live studies are needed to further examine empagliflozin as a new treatment for SIADH.
American Psychological Association (APA)
Refardt, Julie& Winzeler, Bettina& Meienberg, Fabian& Vogt, Deborah R.& Christ-Crain, Mirjam. 2017. Empagliflozin Increases Short-Term Urinary Volume Output in Artificially Induced Syndrome of Inappropriate Antidiuresis. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166613
Modern Language Association (MLA)
Refardt, Julie…[et al.]. Empagliflozin Increases Short-Term Urinary Volume Output in Artificially Induced Syndrome of Inappropriate Antidiuresis. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166613
American Medical Association (AMA)
Refardt, Julie& Winzeler, Bettina& Meienberg, Fabian& Vogt, Deborah R.& Christ-Crain, Mirjam. Empagliflozin Increases Short-Term Urinary Volume Output in Artificially Induced Syndrome of Inappropriate Antidiuresis. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166613