Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus
Joint Authors
Stratmann, Bernd
Richter, Katrin
Wang, Ruichao
Yu, Zhonghao
Xu, Tao
Prehn, Cornelia
Adamski, Jerzy
Tschoepe, Diethelm
Wang-Sattler, Rui
Illig, Thomas
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Coronary artery disease (CAD) is a common complication of type 2 diabetes mellitus (T2D).
This case-control study was done to identify metabolites with different concentrations between T2D patients with and without CAD and to characterise implicated metabolic mechanisms relating to CAD.
Fasting serum samples of 57 T2D subjects, 26 with (cases) and 31 without CAD (controls), were targeted for metabolite profiling of 163 metabolites.
To assess the association between metabolite levels and CAD, partial least squares (PLS) analysis and multivariate logistic regression analysis with adjustment for CAD risk factors and medications were performed.
We observed a separation of cases and controls with two classes of metabolites being significantly associated with CAD, including phosphatidylcholines, and serine.
Four metabolites being independent from the common CAD risk factors displaying best separation between cases and controls were further selected.
Addition of the metabolite concentrations to risk factor analysis raised the area under the receiver-operating-characteristic curve from 0.72 to 0.88 (p=0.020), providing improved sensitivity and specificity for CAD classification.
Serum phospholipid and serine levels independently discriminate T2D patients with and without CAD.
Oxidative stress and reduced antioxidative capacity lead to lower metabolite concentrations probably due to changes in membrane composition and accelerated phospholipid degradation.
American Psychological Association (APA)
Stratmann, Bernd& Richter, Katrin& Wang, Ruichao& Yu, Zhonghao& Xu, Tao& Prehn, Cornelia…[et al.]. 2017. Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166619
Modern Language Association (MLA)
Stratmann, Bernd…[et al.]. Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166619
American Medical Association (AMA)
Stratmann, Bernd& Richter, Katrin& Wang, Ruichao& Yu, Zhonghao& Xu, Tao& Prehn, Cornelia…[et al.]. Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166619
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166619