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Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies
Joint Authors
Yang, Ke-hu
Tian, Liming
Chen, Yaolong
Sun, Jing
Yao, Liang
Fang, Yuan
Yang, Ruifei
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Evidence on the association between subclinical thyroid dysfunction and the risk of cardiovascular outcomes are conflicting.
Methods and Results.
PubMed, EMbase, Web of Science, Cochrane Library, and China Biology Medicine (CBM) databases were searched from inception to July 10, 2016.
A total of 16 studies were included for meta-analysis.
We found that subclinical hypothyroidism was not correlated with coronary heart disease (CHD) (RR = 1.17; 95% CI, 0.91–1.52), total mortality (RR = 1.02; 95% CI, 0.93–1.13), cardiovascular mortality (RR = 1.06; 95% CI, 0.77–1.45), heart failure (RR = 1.17; 95% CI, 0.87–1.57), and atrial fibrillation (RR = 1.05; 95% CI, 0.91–1.21), except CHD mortality (RR = 1.37; 95% CI, 1.03–1.84).
Subgroup analysis indicated a higher estimation risk in CHD (RR = 1.54; 95% CI, 1.00–2.39), cardiovascular mortality (RR = 2.14; 95% CI, 1.43–3.22), and CHD mortality (RR = 1.54; 95% CI, 1.11–2.15) among participants < 65 years.
Furthermore, subclinical hyperthyroidism was found to be associated with CHD (RR = 1.20; 95% CI, 1.02–1.42), total mortality (RR = 1.27; 95% CI, 1.07–1.51), and CHD mortality (RR = 1.45; 95% CI, 1.12–1.86).
Conclusions.
Subclinical hypothyroidism is likely associated with an increased risk of CHD mortality, and subclinical hyperthyroidism is likely associated with increased risk of CHD, CHD mortality, and total mortality.
American Psychological Association (APA)
Sun, Jing& Yao, Liang& Fang, Yuan& Yang, Ruifei& Chen, Yaolong& Yang, Ke-hu…[et al.]. 2017. Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1166623
Modern Language Association (MLA)
Sun, Jing…[et al.]. Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. International Journal of Endocrinology No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1166623
American Medical Association (AMA)
Sun, Jing& Yao, Liang& Fang, Yuan& Yang, Ruifei& Chen, Yaolong& Yang, Ke-hu…[et al.]. Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1166623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166623