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Thyroid-Related Protein Expression in the Human Thymus
Joint Authors
Lee, Kyu Eun
Kim, Mi Jeong
Oh, So Won
Youn, Hyewon
Na, Juri
Kang, Keon Wook
Park, Do Joon
Park, Young Joo
Jang, Ja June
Jung, Kyeong Cheon
Chung, June-Key
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Radioiodine whole body scan (WBS), related to sodium iodide symporter (NIS) function, is widely used to detect recurrence/metastasis in postoperative patients with thyroid cancer.
However, the normal thymic uptake of radioiodine has occasionally been observed in young patients.
We evaluated the expression of thyroid-related genes and proteins in the human thymus.
Thymic tissues were obtained from 22 patients with thyroid cancer patients of all ages.
The expression of NIS, thyroid-stimulating hormone receptor (TSHR), thyroperoxidase (TPO), and thyroglobulin (Tg) was investigated using immunohistochemistry and quantitative RT-PCR.
NIS and TSHR were expressed in 18 (81.8%) and 19 samples (86.4%), respectively, whereas TPO was expressed in five samples (22.7%).
Three thyroid-related proteins were localized to Hassall’s corpuscles and thymocytes.
In contrast, Tg was detected in a single patient (4.5%) localized to vascular endothelial cells.
The expression of thyroid-related proteins was not increased in young thymic tissues compared to that in old thymic tissues.
In conclusion, the expression of NIS and TSHR was detected in the majority of normal thymus samples, whereas that of TPO was detected less frequently, and that of Tg was detected rarely.
The increased thymic uptake of radioiodine in young patients is not due to the increased expression of NIS.
American Psychological Association (APA)
Kim, Mi Jeong& Oh, So Won& Youn, Hyewon& Na, Juri& Kang, Keon Wook& Park, Do Joon…[et al.]. 2017. Thyroid-Related Protein Expression in the Human Thymus. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1166625
Modern Language Association (MLA)
Kim, Mi Jeong…[et al.]. Thyroid-Related Protein Expression in the Human Thymus. International Journal of Endocrinology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1166625
American Medical Association (AMA)
Kim, Mi Jeong& Oh, So Won& Youn, Hyewon& Na, Juri& Kang, Keon Wook& Park, Do Joon…[et al.]. Thyroid-Related Protein Expression in the Human Thymus. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1166625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166625