Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods
Joint Authors
Paprocka, Justyna
Sokół, Maria
Kijonka, Marek
Boguszewicz, Łukasz
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy.
Material and Methods.
Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC.
The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n=76) and the children from the control, nonepileptic group (n=36).
To describe the diurnal melatonin secretion, mathematical model was constructed and nonlinear least squares method with the Levenberg-Marquardt optimization algorithm was applied to approximate its parameters.
The dim light melatonin onset (DLMO) parameters were also estimated from the model.
Results and Conclusions.
Statistically significant differences were found between the TSC melatonin secretion profiles and the nonepileptic control group.
The profiles for the epileptic and TSC groups were found to be similar.
For the TSC group, though a small one, the variations in the MLT release amplitudes seem to be independent of the total number of seizures; however, the MLT release shift appears to depend on the number of seizures.
American Psychological Association (APA)
Paprocka, Justyna& Kijonka, Marek& Boguszewicz, Łukasz& Sokół, Maria. 2017. Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166640
Modern Language Association (MLA)
Paprocka, Justyna…[et al.]. Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods. International Journal of Endocrinology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1166640
American Medical Association (AMA)
Paprocka, Justyna& Kijonka, Marek& Boguszewicz, Łukasz& Sokół, Maria. Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166640