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RNF43 Mutations in IPMN Cases: A Potential Prognostic Factor
Joint Authors
Chang, Xiao Yan
Wu, Yan
Jiang, Ying
Wang, Peng Yan
Chen, Jie
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
An intraductal papillary mucinous neoplasm (IPMN) is a common pancreatic precursor lesion, and it often harbors mutations in KRAS, GNAS, and RNF43.
To clarify the molecular profiles of IPMNs, we conducted mutation analysis of KRAS, GNAS, and RNF43 in 61 IPMN formalin-fixed, paraffin-embedded (FFPE) specimens.
The mutation rates of codons 12, 13, and 61 in KRAS and codon 201 in GNAS were detected by Sanger sequencing.
Next-generation sequencing was performed on RNF43, and the results were further verified by Sanger sequencing.
We identified KRAS and GNAS mutations in 35 (57%) and 40 (66%) IPMN cases, respectively.
GNAS mutations were significantly correlated with the morphologic subtype (P<0.001) and were more prevalent in the intestinal subtype (93%) than in the gastric (55%) and pancreatobiliary subtypes (44%) but were absent in the oncocytic subtype.
RNF43 mutations were found in 5 cases (8%), all of which occurred in high-grade dysplasia and invasive lesions (2/5 and 3/5).
All 5 cases harboring RNF43 mutations also exhibited GNAS mutations.
RNF43 mutations were associated with a worse prognosis in invasive IPMN patients (P=0.002), while KRAS and GNAS mutations did not affect the prognosis of patients.
American Psychological Association (APA)
Chang, Xiao Yan& Wu, Yan& Jiang, Ying& Wang, Peng Yan& Chen, Jie. 2020. RNF43 Mutations in IPMN Cases: A Potential Prognostic Factor. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1166643
Modern Language Association (MLA)
Chang, Xiao Yan…[et al.]. RNF43 Mutations in IPMN Cases: A Potential Prognostic Factor. Gastroenterology Research and Practice No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1166643
American Medical Association (AMA)
Chang, Xiao Yan& Wu, Yan& Jiang, Ying& Wang, Peng Yan& Chen, Jie. RNF43 Mutations in IPMN Cases: A Potential Prognostic Factor. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1166643
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166643