More Favorable Metabolic Impact of Three-Times-Weekly versus Daily Growth Hormone Treatment in Naïve GH-Deficient Children
Joint Authors
Giordano, Carla
Ciresi, Alessandro
Cicciò, Floriana
Radellini, Stefano
Guarnotta, Valentina
Calcaterra, Anna Maria
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate whether two different regimens of weekly injections could lead to similar auxological and metabolic effects in children with growth hormone deficiency (GHD).
Design.
32 GHD children (25 males, mean age 10.5 ± 2.2 yr) were randomly assigned to receive daily (group A, 16 patients) or TIW (group B, 16 patients) GHT for 12 months.
Methods.
Auxological parameters, insulin-like growth factor-I (IGF-I), glucose and insulin during OGTT, glycosylated hemoglobin (HbA1c), lipid profile, the oral disposition index (DIo), the homeostasis model assessment estimate of insulin resistance (Homa-IR), and the insulin sensitivity index (ISI).
Results.
After 12 months, both groups showed a significant and comparable improvement in height (p<0.001) and IGF-I (p<0.001).
As regards the metabolic parameters, in both groups, we found a significant increase in fasting insulin (p<0.001 and p=0.026) and Homa-IR (p<0.001 and p=0.019).
A significant increase in fasting glucose (p=0.001) and a decrease in ISI (p<0.001) and DIo (p=0.002) were only found in group A.
Conclusions.
The TIW regimen is effective and comparable with the daily regimen in improving auxological parameters and has a more favorable metabolic impact in GHD children.
This trial is registered with ClinicalTrials.gov NCT03033121.
American Psychological Association (APA)
Ciresi, Alessandro& Cicciò, Floriana& Radellini, Stefano& Guarnotta, Valentina& Calcaterra, Anna Maria& Giordano, Carla. 2017. More Favorable Metabolic Impact of Three-Times-Weekly versus Daily Growth Hormone Treatment in Naïve GH-Deficient Children. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166656
Modern Language Association (MLA)
Ciresi, Alessandro…[et al.]. More Favorable Metabolic Impact of Three-Times-Weekly versus Daily Growth Hormone Treatment in Naïve GH-Deficient Children. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166656
American Medical Association (AMA)
Ciresi, Alessandro& Cicciò, Floriana& Radellini, Stefano& Guarnotta, Valentina& Calcaterra, Anna Maria& Giordano, Carla. More Favorable Metabolic Impact of Three-Times-Weekly versus Daily Growth Hormone Treatment in Naïve GH-Deficient Children. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166656