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DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps
Joint Authors
Zhang, Jingjie
Liu, Na
Meng, Xianmei
Jia, Yanbin
Gong, Kerui
Shao, Guo
Dang, Tong
Zhang, Wei
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-01
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Background.
It is pretty well known that DNA methyltransferases (DNMTs) are actively involved in abnormal cell growth.
The goal of the current study is to explore the correlation between DNMT expression and colorectal adenomatous polyps (CAPs).
Method.
Twenty pairs of CAP samples with a diameter≥10 mm and corresponding normal colorectal mucosa (NCM) tissues from patients were used in the present study.
The expression levels and activity of DNA methyltransferases (DNMTs) were measured in the CAP tissues.
The global methylation and the promoter methylation level of 3 kinds of tumour suppressor gene were detected.
Results.
mRNA and protein levels of DNMT3B were found to be elevated in the CAP tissues compared with the control tissue.
Additionally, the methylation of long interspersed nuclear elements-1 (LINE-1/L1) was decreased in the CAP tissue.
Furthermore, methylation of the promoter of a tumour suppressor gene Ras association domain family 1A (RASSF1A) was increased in the CAP tissues, while the mRNA levels of RASSF1A were decreased.
Conclusions.
These results suggest that the overexpression of DNMT3B may contribute to a role in the genesis of CAPs through the hypomethylation of chromosomes in the whole cell and promoter hypermethylation of RASSF1A.
American Psychological Association (APA)
Meng, Xianmei& Liu, Na& Jia, Yanbin& Gong, Kerui& Zhang, Jingjie& Zhang, Wei…[et al.]. 2020. DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1166659
Modern Language Association (MLA)
Meng, Xianmei…[et al.]. DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps. Gastroenterology Research and Practice No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1166659
American Medical Association (AMA)
Meng, Xianmei& Liu, Na& Jia, Yanbin& Gong, Kerui& Zhang, Jingjie& Zhang, Wei…[et al.]. DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1166659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166659