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Propranolol Is Associated with Lower Risk of Incidence of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Tertiary-Center Study and Indirect Comparison with Meta-Analysis
Joint Authors
Lin, Han Chieh
Hou, Ming-Chih
Tsai, Hung-Cheng
Li, Tzu-Hao
Liu, Chih-Wei
Huang, Shiang-Fen
Yang, Ying-Ying
Hsieh, Yun-Cheng
Liu, Hsuan-Miao
Tsai, Yu-Lien
Hsu, Chien-Fu
Huang, Chia-Chang
Lee, Tzung-Yan
Tsai, Chang-Youh
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alcoholic cirrhosis (AC) leads to enormous disease burden and occupies a substantial proportion in the etiology of hepatocellular carcinoma (HCC), but scarce attention has been paid to this topic.
Besides, propranolol has been reported to decrease the rate of HCC in viral hepatitis.
We conducted a retrospective tertiary-center cohort study to identify the HCC incidence in AC patients with or without propranolol.
A total of 1,046 AC patients with hospitalization had been screened, and those with regular follow-up for three years or otherwise until the date of malignancy diagnosis without meeting exclusion criteria were enrolled; finally, 23 AC patients with propranolol and 46 AC patients without propranolol were analyzed after twofold propensity-score matching.
The cumulative incidence of HCC was lower in the propranolol group (log-rank test, P=0.046).
Furthermore, we undertook the meta-analysis of annual incidence of HCC in AC patients, and 1,949 publications were screened, within which eight studies were analyzed; the pooled annual incidence was 2.41%, which was higher than the calculated annual incidence of HCC in our AC cohort with propranolol (1.45%).
In conclusion, propranolol is associated with decreased risk of HCC incidence in patients with AC.
American Psychological Association (APA)
Li, Tzu-Hao& Tsai, Yu-Lien& Hsu, Chien-Fu& Liu, Chih-Wei& Huang, Chia-Chang& Yang, Ying-Ying…[et al.]. 2020. Propranolol Is Associated with Lower Risk of Incidence of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Tertiary-Center Study and Indirect Comparison with Meta-Analysis. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1166662
Modern Language Association (MLA)
Li, Tzu-Hao…[et al.]. Propranolol Is Associated with Lower Risk of Incidence of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Tertiary-Center Study and Indirect Comparison with Meta-Analysis. Gastroenterology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1166662
American Medical Association (AMA)
Li, Tzu-Hao& Tsai, Yu-Lien& Hsu, Chien-Fu& Liu, Chih-Wei& Huang, Chia-Chang& Yang, Ying-Ying…[et al.]. Propranolol Is Associated with Lower Risk of Incidence of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Tertiary-Center Study and Indirect Comparison with Meta-Analysis. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1166662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166662