COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges
Joint Authors
Burlacu, Alexandru
Popa, Iolanda Valentina
Diculescu, Mircea
Mihai, Cătălina
Cijevschi-Prelipcean, Cristina
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The novel coronavirus SARS-CoV-2 causing COVID-19 disease is yielding a global outbreak with severe threats to public health.
In this paper, we aimed at reviewing the current knowledge about COVID-19 infectious risk status in inflammatory bowel disease (IBD) patients requiring immunosuppressive medication.
We also focused on several molecular insights that could explain why IBD patients appear not to have higher risks of infection and worse outcomes in COVID-19 than the general population in an attempt to provide scientific support for safer decisions in IBD patient care.
Methods.
PubMed electronic database was interrogated for relevant articles involving data about common molecular pathways and shared treatment strategies between SARS-CoV-2, SARS-CoV-1, MERS-CoV, and inflammatory bowel diseases.
Besides, Neural Covidex, an artificial intelligence tool, was used to answer queries about pathogenic coronaviruses and possible IBD interactions using the COVID-19 Open Research Dataset (CORD-19).
Discussions.
Few molecular and therapeutic interactions between IBD and pathogenic coronaviruses were explored.
First, we showed how the activity of soluble angiotensin-converting enzyme 2, CD209L other receptors, and phosphorylated α subunit of eukaryotic translation initiation factor 2 might exert protective impact in IBD in case of coronavirus infection.
Second, IBD medication was discussed in the context of possible beneficial effects on COVID-19 pathogeny, including “cytokine storm” prevention and treatment, immunomodulation, interferon signaling blocking, and viral endocytosis inhibition.
Conclusions.
Using the current understanding of SARS-CoV-2 as well as other pathogenic coronaviruses immunopathology, we showed why IBD patients should not be considered at an increased risk of infection or more severe outcomes.
Whether our findings are entirely applicable to the pathogenesis, disease susceptibility, and treatment management of SARS-CoV-2 infection in IBD must be further explored.
American Psychological Association (APA)
Popa, Iolanda Valentina& Diculescu, Mircea& Mihai, Cătălina& Cijevschi-Prelipcean, Cristina& Burlacu, Alexandru. 2020. COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1166663
Modern Language Association (MLA)
Popa, Iolanda Valentina…[et al.]. COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges. Gastroenterology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1166663
American Medical Association (AMA)
Popa, Iolanda Valentina& Diculescu, Mircea& Mihai, Cătălina& Cijevschi-Prelipcean, Cristina& Burlacu, Alexandru. COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1166663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166663