BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults
Joint Authors
Xu, Min
Wang, Wei-qing
Wang, Yanqiu
Yin, Qinglei
Ni, Qicheng
Wang, Qidi
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The impacts of thyroid hormones (TH) on lipid profile in euthyroid adults have gained much attention.
It is currently unknown whether BMI influences such interaction.
In the present study, we investigate the role of BMI in modulating the association between TH and lipid parameters in 1372 euthyroid healthy adults.
Our results show that thyroid parameters are differentially associated with lipid profile.
FT3 is positively correlated with total cholesterol (β=0.176±0.046, P<0.001) and LDL cholesterol levels (β=0.161±0.040, P<0.001).
FT4 is negatively correlated with TG (β=−0.087±0.029, P<0.01) while positively correlated with HDL cholesterol levels (β=0.013±0.005, P<0.01).
TSH is positively associated with TG (β=0.145±0.056, P<0.05) and total cholesterol levels (β=0.094±0.030, P<0.01).
Importantly, BMI modulates the effect of TH on lipid profile: the interaction of FT4 and BMI and the interaction of FT3 and BMI reach statistical significance in predicting TG and HDL cholesterol levels, respectively.
Stratified according to BMI levels, most associations between TH and lipid profile are significant only in normal-weight group.
In conclusion, in euthyroid adults, high normal FT3, TSH levels, and low normal FT4 levels are associated with unfavorable lipid profile.
BMI mediates the effect of thyroid function on lipid profile in euthyroid adults.
American Psychological Association (APA)
Wang, Yanqiu& Yin, Qinglei& Xu, Min& Ni, Qicheng& Wang, Wei-qing& Wang, Qidi. 2017. BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166671
Modern Language Association (MLA)
Wang, Yanqiu…[et al.]. BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166671
American Medical Association (AMA)
Wang, Yanqiu& Yin, Qinglei& Xu, Min& Ni, Qicheng& Wang, Wei-qing& Wang, Qidi. BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166671
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166671