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The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery
Joint Authors
Xin, Cheng
Yu, Guan-Yu
Zheng, Kuo
Zheng, Nanxin
Zhou, Leqi
Sun, Ge
Wen, Rongbo
Zhang, Hang
Bai, Chenguang
Zhang, Wei
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The prognostic value of tumor deposit (TD) count in colorectal cancer (CRC) patients has been rarely evaluated.
This study is aimed at exploring the prognostic value of TD count and finding out the optimal cutoff point of TD count to differentiate the prognoses of TD-positive CRC patients.
Method.
Patients diagnosed with CRC from Surveillance, Epidemiology, and End Results (SEER) database from January 1, 2010, to December 31, 2012, were analyzed.
X-tile program was used to identify the optimal cutoff point of TD count in training cohort, and a validation cohort was used to test this cutoff point after propensity score matching (PSM).
Univariate and multivariate Cox proportional hazard models were used to assess the risk factors of survival.
Results.
X-tile plots identified 3 (P<0.001) as the optimal cutoff point of TD count to divide the patients of training cohort into high and low risk subsets in terms of disease-specific survival (DSS).
This cutoff point was validated in validation cohort before and after PSM (P<0.001, P=0.002).
More TD count, which was defined as more than 3, was validated as an independent risk prognostic factor in univariate and multivariate analysis (P<0.001).
Conclusion.
More TD count (TD count≥4) was significantly associated with poor disease-specific survival in CRC patients.
American Psychological Association (APA)
Zheng, Kuo& Zheng, Nanxin& Xin, Cheng& Zhou, Leqi& Sun, Ge& Wen, Rongbo…[et al.]. 2020. The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1166677
Modern Language Association (MLA)
Zheng, Kuo…[et al.]. The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery. Gastroenterology Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1166677
American Medical Association (AMA)
Zheng, Kuo& Zheng, Nanxin& Xin, Cheng& Zhou, Leqi& Sun, Ge& Wen, Rongbo…[et al.]. The Prognostic Significance of Tumor Deposit Count for Colorectal Cancer Patients after Radical Surgery. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1166677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166677