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Serum Carbohydrate Antigen 199 as a Biomarker for Evaluating Patients with Choledocholithiasis
Joint Authors
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims.
Choledocholithiasis is a common and yet potentially debilitating disease of the biliary tract.
While certain patients with this disease remain largely asymptomatic or experience mild discomfort, in several cases, patient can suffer biliary inflammation and other serious symptoms.
Previous studies have detected elevated serum levels of carbohydrate antigen 199 in patients with choledocholithiasis.
We wanted to know whether serum CA199 level in patients with choledocholithiasis is related to the level of inflammation in patients.
Methods.
In the present study, we separated a cohort of 135 choledocholithiasis patients into two groups based on their white blood cell counts, which were either 3.5−9.5×109/L or ≥9.5×109/L.
We also divided patients into two groups according to CPR < 10 mg/L and CRP ≥ 10 mg/L.
At the same time, the correlation between CA199 and CRP level was analyzed.
Results.
We then used a Rank-sum test to compare serum carbohydrate 199 levels between these groups, revealing significantly higher levels of this antigen in patients with a white cell count ≥9.5×109/L (Z=−3.584, P<0.01).
The two groups were grouped by CRP, and the CA199 level was compared.
The difference between the two groups was statistically significant (P<0.01).
The correlation analysis between CA199 and CRP showed an obvious correlation (r=0.574).
Conclusion.
This suggests that in patients with choledocholithiasis, higher circulating carbohydrate antigen 199 levels may correspond to a higher degree of inflammation.
American Psychological Association (APA)
Gu, Wang& Tong, Zhong. 2020. Serum Carbohydrate Antigen 199 as a Biomarker for Evaluating Patients with Choledocholithiasis. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1166725
Modern Language Association (MLA)
Gu, Wang& Tong, Zhong. Serum Carbohydrate Antigen 199 as a Biomarker for Evaluating Patients with Choledocholithiasis. Gastroenterology Research and Practice No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1166725
American Medical Association (AMA)
Gu, Wang& Tong, Zhong. Serum Carbohydrate Antigen 199 as a Biomarker for Evaluating Patients with Choledocholithiasis. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1166725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166725