Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues
Joint Authors
Li, Yiming
Liu, Wenjuan
Xie, Lina
He, Min
Shen, Ming
Zhu, Jingjing
Yang, Yeping
Wang, Meng
Hu, Ji
Ye, Hongying
Zhao, Yao
Zhang, Zhaoyun
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to somatostatin analogues (SSA).
Our aim was to evaluate the value of the immunohistochemical (IHC) scores of 2 subtypes, SSTR2 and SSTR5, in predicting the short-term efficacy of SSA therapy in patients with active acromegaly.
Ninety-three newly diagnosed acromegalic patients were included in our study.
These patients were categorized into either a SSA-pretreated group (SA, n=63) or a direct-surgery group (DS, n=30), depending on whether or not presurgical SSA treatment was received.
IHC analysis, using a 12-grade scoring system, with rabbit monoclonal antibodies against SSTR2 and SSTR5, was performed on all adenoma tissues.
The reduction of GH, IGF-1, and tumor size after treatment with SSA for 3 months was measured.
Compared with that in the DS group, SSTR2 expression was lower in the SA group.
Additionally, in the SA group, SSTR2 expression was positively correlated with the reduction of IGF-1 and tumor volume.
However, there was no correlation between the SSTR5 score and the efficacy of SSA.
In conclusion, the protein expression of SSTR2, but not of SSTR5, is a valuable indicator in predicting biochemical and tumor size response to short-term SSA treatment in acromegalic patients.
American Psychological Association (APA)
Liu, Wenjuan& Xie, Lina& He, Min& Shen, Ming& Zhu, Jingjing& Yang, Yeping…[et al.]. 2017. Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166739
Modern Language Association (MLA)
Liu, Wenjuan…[et al.]. Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues. International Journal of Endocrinology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1166739
American Medical Association (AMA)
Liu, Wenjuan& Xie, Lina& He, Min& Shen, Ming& Zhu, Jingjing& Yang, Yeping…[et al.]. Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166739