S100A12 in Digestive Diseases and Health: A Scoping Review
Joint Authors
Gaddy, Jennifer A.
Carvalho, Alexandre
Lu, Jacky
Francis, Jamisha D.
Moore, Rebecca E.
Haley, Kathryn P.
Doster, Ryan S.
Townsend, Steven D.
Johnson, Jeremiah G.
Damo, Steven M.
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Calgranulin proteins are an important class of molecules involved in innate immunity.
These members of the S100 class of the EF-hand family of calcium-binding proteins have numerous cellular and antimicrobial functions.
One protein in particular, S100A12 (also called EN-RAGE or calgranulin C), is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation.
Structure-function analyses reveal that S100A12 has the capacity to bind calcium, zinc, and copper, processes that contribute to nutritional immunity against invading microbial pathogens.
S100A12 is a ligand for the receptor for advanced glycation end products (RAGE), toll-like receptor 4 (TLR4), and CD36, which promote cellular and immunological pathways to alter inflammation.
We conducted a scoping review of the existing literature to define what is known about the association of S100A12 with digestive disease and health.
Results suggest that S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn’s disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers.
Together, these results reveal S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases.
American Psychological Association (APA)
Carvalho, Alexandre& Lu, Jacky& Francis, Jamisha D.& Moore, Rebecca E.& Haley, Kathryn P.& Doster, Ryan S.…[et al.]. 2020. S100A12 in Digestive Diseases and Health: A Scoping Review. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1166740
Modern Language Association (MLA)
Carvalho, Alexandre…[et al.]. S100A12 in Digestive Diseases and Health: A Scoping Review. Gastroenterology Research and Practice No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1166740
American Medical Association (AMA)
Carvalho, Alexandre& Lu, Jacky& Francis, Jamisha D.& Moore, Rebecca E.& Haley, Kathryn P.& Doster, Ryan S.…[et al.]. S100A12 in Digestive Diseases and Health: A Scoping Review. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1166740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166740