Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis
Joint Authors
Tong, Yilin
Zhu, Yanmei
Zhao, Yan
Shan, Zexing
Zhang, Jianjun
Liu, Dong
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Tumor regression grade (TRG) is widely used in gastrointestinal carcinoma to evaluate pathological responses to neoadjuvant chemotherapy (NCT), but whether it is an independent prognostic factor is still controversial.
The aim of this study is to investigate the value of TRG in locally advanced gastric adenocarcinoma patients who underwent NCT and curative resection.
Methods.
Pathological regression was reevaluated according to the Mandard TRG.
Survival curves were obtained by the Kaplan–Meier method, and differences in overall survival (OS) and disease-free survival (DFS) were compared using the log-rank test.
Univariate and multivariate analyses for survival were based on the Cox proportional hazards method.
Results.
In total, 290 patients were identified in our electronic database.
In univariable analysis, TRG was associated with OS (HR=3.822, P≤0.001) and DFS (HR=3.374, P≤0.001).
However, in multivariable analysis, TRG was not an independent factor for OS (P=0.231) or DFS (P=0.191).
In the stratified analysis, TRG retrieved prognostic significance in patients with the metastasis of lymph node (HR=2.034, P=0.035 for OS; HR=2.220, P=0.016 for DFS), while not in patients with negative lymph node (P=0.296 for OS; P=0.172 for DFS).
Conclusions.
TRG was not an independent predictor for survival, but the system regained its predicting significance in patients with lymph node metastasis.
American Psychological Association (APA)
Tong, Yilin& Zhu, Yanmei& Zhao, Yan& Shan, Zexing& Zhang, Jianjun& Liu, Dong. 2020. Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1166763
Modern Language Association (MLA)
Tong, Yilin…[et al.]. Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis. Gastroenterology Research and Practice No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1166763
American Medical Association (AMA)
Tong, Yilin& Zhu, Yanmei& Zhao, Yan& Shan, Zexing& Zhang, Jianjun& Liu, Dong. Tumor Regression Grade Predicts Survival in Locally Advanced Gastric Adenocarcinoma Patients with Lymph Node Metastasis. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1166763
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166763