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Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis
Joint Authors
Mancuso, Andrea
Qi, Xingshun
Xu, Xiangbo
Zhou, Xinmiao
Li, Miaomiao
Romeiro, Fernando Gomes
Guo, Zeqi
Zhang, Jingqiao
Feng, Ruirui
Hong, Cen
Zhang, Dan
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background and Aim.
Liver cirrhosis is often accompanied by insidious cardiac dysfunction.
This retrospective cross-sectional study is aimed at exploring the correlation between serum cardiac markers and decompensating events in liver cirrhosis.
Methods.
Cirrhotic patients who were consecutively hospitalized between January 2016 and March 2019 were screened.
Serum cardiac biomarkers at admission, including N-Terminal pro-B-type natriuretic peptide (NT-pro BNP), high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase (CK), creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH), were collected.
Acute decompensating events at admission, primarily including ascites, acute gastrointestinal hemorrhage, and acute-on-chronic liver failure (ACLF), were recorded.
Results.
The NT-pro BNP level was significantly higher in cirrhotic patients with acute decompensating events than in those without any decompensating events (median: 140.75 pg/mL versus 41.86 pg/mL, P<0.001).
The NT-pro BNP level significantly correlated with ascites, acute gastrointestinal hemorrhage, and ACLF.
The hs-cTnT level was significantly higher in cirrhotic patients with acute decompensating events than in those without decompensating events (median: 0.008 ng/mL versus 0.006 ng/mL, P=0.007).
The hs-cTnT level significantly correlated with acute gastrointestinal hemorrhage, but not ascites or ACLF.
LDH (185.0 U/L versus 173.5 U/L, P=0.281), CK (71 U/L versus 84 U/L, P=0.157), and CK-MB (29.5 U/L versus 33.0 U/L, P=0.604) levels were not significantly different between cirrhotic patients with and without acute decompensating events.
Conclusion.
The elevated NT-pro BNP level seems to be closely related to the development of acute decompensating events in liver cirrhosis.
American Psychological Association (APA)
Li, Miaomiao& Guo, Zeqi& Zhang, Dan& Xu, Xiangbo& Romeiro, Fernando Gomes& Mancuso, Andrea…[et al.]. 2020. Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1166785
Modern Language Association (MLA)
Li, Miaomiao…[et al.]. Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis. Gastroenterology Research and Practice No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1166785
American Medical Association (AMA)
Li, Miaomiao& Guo, Zeqi& Zhang, Dan& Xu, Xiangbo& Romeiro, Fernando Gomes& Mancuso, Andrea…[et al.]. Correlation of Serum Cardiac Markers with Acute Decompensating Events in Liver Cirrhosis. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1166785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166785