Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer
Joint Authors
Zou, Qi
Wang, Xiaolin
Ren, Donglin
Bai, Liangliang
Tang, Guannan
Huang, Meijin
Luo, Yanxin
Yu, Huichuan
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The interventions for hemorrhoid increase access to rectal cancer screening and thus might reduce cancer death.
We aimed to examine the impact of hemorrhoid on survival outcomes in rectal cancer.
Methods.
We identified 510 patients with stage I to III rectal cancer from a prospectively collected database.
Patients were divided into hemorrhoid and non-hemorrhoid group.
The primary endpoints were disease-free survival (DFS) and overall survival (OS).
Results.
Hemorrhoid group had significantly more stage I-II diseases in comparison to nonhemorrhoid group (71.1% vs.
55.9%, P=0.049).
The hemorrhoid group had significantly better DFS and OS compared to nonhemorrhoid group, the hazard ratios (HRs) of which were 0.39 (95% CI 0.17-0.88, P=0.018) and 0.33 (95% CI 0.12-0.92, P=0.034), respectively.
Multivariate analysis revealed that hemorrhoid was independently associated with DFS [adjusted HR 0.43 (95% CI 0.17-0.95, P=0.045)].
A nomogram for predicting DFS outcome was generated based on hemorrhoid history, with a concordance index of 0.71 (95% CI 0.66-0.75, P<0.001).
Conclusions.
There may exist a screening effect and survival benefit from hemorrhoid in rectal cancer, which supports the significance of rectal cancer screening in lowering its mortality.
American Psychological Association (APA)
Zou, Qi& Ren, Donglin& Wang, Xiaolin& Bai, Liangliang& Tang, Guannan& Huang, Meijin…[et al.]. 2020. Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1166869
Modern Language Association (MLA)
Zou, Qi…[et al.]. Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer. Gastroenterology Research and Practice No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1166869
American Medical Association (AMA)
Zou, Qi& Ren, Donglin& Wang, Xiaolin& Bai, Liangliang& Tang, Guannan& Huang, Meijin…[et al.]. Improved Survival Outcome and Access to Cancer Screening from Hemorrhoid in Patients with Rectal Cancer. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1166869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166869