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Diagnostic Value of Plasma miR-181b, miR-196a, and miR-210 Combination in Pancreatic Cancer
Joint Authors
Liu, Gongpan
Shao, Cunhua
Li, Anyun
Zhang, Xiaobin
Guo, Xingjun
Li, Jiangong
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
This study was aimed at investigating the roles of plasma miR-181b, miR-196a, and miR-210 in the diagnosis of pancreatic cancer (PC).
Methods.
Plasma samples were isolated from 40 patients with PC and 40 healthy individuals, respectively.
The expression of miR-181b, miR-196a, and miR-210 was detected by qRT-PCR.
The level of carbohydrate antigen 199 (CA199) was measured by an electrochemiluminescence (ECL) assay.
The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of miR-181b, miR-196a, miR-210, CA199, and their combinations in PC.
Results.
The expression of plasma miR-181b, miR-196a, and miR-210 was significantly upregulated in PC patients.
The plasma level of CA199 was also significantly increased in PC patients.
The expression of miR-181b, miR-196a, and miR-210 was closely associated with lymph node metastasis, clinical stage, and vascular invasion but not correlated with age, gender, and tumor size.
miR-181b, miR-196a, and miR-210 have lower AUC than CA199 in the diagnosis of PC.
miR-181b+miR-210 and miR-196a+miR-210 also have lower AUC than CA199.
It is worth noting that miR-181b+miR-196a+miR-210 has a higher AUC than CA199 in the diagnosis of PC.
Conclusion.
The combination of plasma miR-181b, miR-196a, and miR-210 had a good diagnostic value for PC.
American Psychological Association (APA)
Liu, Gongpan& Shao, Cunhua& Li, Anyun& Zhang, Xiaobin& Guo, Xingjun& Li, Jiangong. 2020. Diagnostic Value of Plasma miR-181b, miR-196a, and miR-210 Combination in Pancreatic Cancer. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1166913
Modern Language Association (MLA)
Liu, Gongpan…[et al.]. Diagnostic Value of Plasma miR-181b, miR-196a, and miR-210 Combination in Pancreatic Cancer. Gastroenterology Research and Practice No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1166913
American Medical Association (AMA)
Liu, Gongpan& Shao, Cunhua& Li, Anyun& Zhang, Xiaobin& Guo, Xingjun& Li, Jiangong. Diagnostic Value of Plasma miR-181b, miR-196a, and miR-210 Combination in Pancreatic Cancer. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1166913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166913