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Small-Bowel Lesions in Patients Taking Direct Oral Anticoagulants Detected Using Capsule Endoscopy
Joint Authors
Yamamoto, Toshimasa
Mimura, Toshihide
Yamaoka, Minoru
Imaeda, Hiroyuki
Hosoe, Naoki
Yoneno, Kazuaki
Kanno, Ryu
Mitsufuji, Takashi
Sasaki, Takahiro
Akiyama, Yuji
Ohgo, Hideki
Morohoshi, Yuichi
Kanai, Takanori
Ogata, Haruhiko
Yamamoto, Keiji
Nakamoto, Hidetomo
Araki, Nobuo
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Aim.
Direct oral anticoagulant- (DOAC-) induced small-bowel lesions have not been described.
We evaluated small-bowel lesions related to DOAC using video capsule endoscopy (VCE).
Methods.
This study was a prospective, open-label, nonblinded, multicenter, and observational study.
From September 2013 to March 2017, patients taking DOACs were enrolled.
Patients underwent VCE.
The type and location of small-bowel lesions were registered.
Also, (1) the proportion of lesions detected between types of DOAC was evaluated and (2) the hemoglobin (Hb) and serum ferritin levels were compared between patients with and without small-bowel lesions.
Results.
33 patients were enrolled, but 4 patients withdrew their consent, and VCE was performed on 29 patients.
Eight, 13, and 8 patients received dabigatran, rivaroxaban, and apixaban, respectively.
Small-bowel transit was complete in 27 of 29 patients (93.1%).
Small-bowel lesions were detected in 23 (79.3%), redness in 12 (41.4%), erosions in 14 (48.3%), and angioectasia in 3 (10.3%) patients, and 6 patients (20.7%) had no abnormalities.
Redness and erosions were detected in the upper, middle, or lower portions, but erosions tended to be less frequent in the middle portion (p=0.25, 0.06).
Angioectasia was not detected in the lower portion.
No patients had active bleeding.
The findings did not differ according to the drug.
The relationships between the endoscopic findings and the Hb and serum ferritin levels were not significant.
Conclusion.
Many patients taking DOACs had small-bowel lesions; however, most lesions were relatively mild.
Observing small-bowel lesions over longer periods may be necessary in patients taking DOACs.
This trial is registered with UMIN000011527.
American Psychological Association (APA)
Yamaoka, Minoru& Imaeda, Hiroyuki& Hosoe, Naoki& Yoneno, Kazuaki& Kanno, Ryu& Mitsufuji, Takashi…[et al.]. 2020. Small-Bowel Lesions in Patients Taking Direct Oral Anticoagulants Detected Using Capsule Endoscopy. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1166978
Modern Language Association (MLA)
Yamaoka, Minoru…[et al.]. Small-Bowel Lesions in Patients Taking Direct Oral Anticoagulants Detected Using Capsule Endoscopy. Gastroenterology Research and Practice No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1166978
American Medical Association (AMA)
Yamaoka, Minoru& Imaeda, Hiroyuki& Hosoe, Naoki& Yoneno, Kazuaki& Kanno, Ryu& Mitsufuji, Takashi…[et al.]. Small-Bowel Lesions in Patients Taking Direct Oral Anticoagulants Detected Using Capsule Endoscopy. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1166978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166978