An Integrating Approach for Genome-Wide Screening of MicroRNA Polymorphisms Mediated Drug Response Alterations
Joint Authors
Wang, Qianghu
Wang, Xianyue
Wu, Wei
Zhang, Rongxin
Wu, Lingxiang
Chen, Huan
Li, Pengping
Nie, Yumin
Shao, Jiaofang
Li, Yan
Lin, Xue
Hu, Jie
Jiang, Hong
Lv, Sali
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are a class of evolutionarily conserved small noncoding RNAs, ~22 nt in length, and found in diverse organisms and play important roles in the regulation of mRNA translation and degradation.
It was shown that miRNAs were involved in many key biological processes through regulating the expression of targets.
Genetic polymorphisms in miRNA target sites may alter miRNA regulation and therefore result in the alterations of the drug targets.
Recent studies have demonstrated that SNPs in miRNA target sites can affect drug efficiency.
However, there are still a large number of specific genetic variants related to drug efficiency that are yet to be discovered.
We integrated large scale of genetic variations, drug targets, gene interaction networks, biological pathways, and seeds region of miRNA to identify miRNA polymorphisms affecting drug response.
In addition, harnessing the abundant high quality biological network/pathways, we evaluated the cascade distribution of tarSNP impacts.
We showed that the predictions can uncover most of the known experimentally supported cases as well as provide informative candidates complementary to existing methods/tools.
Although there are several existing databases predicting the gain or loss of targeting function of miRNA mediated by SNPs, such as PolymiRTS, miRNASNP, MicroSNiPer, and MirSNP, none of them evaluated the influences of tarSNPs on drug response alterations.
We developed a user-friendly online database of this approach named Mir2Drug.
American Psychological Association (APA)
Wang, Xianyue& Jiang, Hong& Wu, Wei& Zhang, Rongxin& Wu, Lingxiang& Chen, Huan…[et al.]. 2017. An Integrating Approach for Genome-Wide Screening of MicroRNA Polymorphisms Mediated Drug Response Alterations. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166979
Modern Language Association (MLA)
Wang, Xianyue…[et al.]. An Integrating Approach for Genome-Wide Screening of MicroRNA Polymorphisms Mediated Drug Response Alterations. International Journal of Genomics No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1166979
American Medical Association (AMA)
Wang, Xianyue& Jiang, Hong& Wu, Wei& Zhang, Rongxin& Wu, Lingxiang& Chen, Huan…[et al.]. An Integrating Approach for Genome-Wide Screening of MicroRNA Polymorphisms Mediated Drug Response Alterations. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166979