![](/images/graphics-bg.png)
Hemodialysis Increases the Risk of Lower Gastrointestinal Bleeding and Angiodysplasia Bleeding: A Nationwide Population Study
Joint Authors
Chen, Wen-Chih
Tsai, Tzung-Jiun
Huang, Yu-Tung
Yang, Yi-Hsin
Feng, I-Che
Wu, Wen-Chieh
Hu, Huang-Ming
Hsu, Ping-I
Wu, Deng-Chyang
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Patients with chronic kidney disease (CKD) with or without hemodialysis were considered to have bleeding tendency and higher risk for gastrointestinal (GI) bleeding.
Previous studies had documented that hemodialysis may increase the gastroduodenal ulcer bleeding.
Few studies evaluated the relationship between CKD and lower GI bleeding.
Materials and Methods.
An observational cohort study design was conducted.
The end-stage renal disease (ESRD) patients receiving regular hemodialysis (dialysis CKD), CKD patients without dialysis (dialysis-free CKD), and controls were selected from 1 million randomly sampled subjects in the National Health Insurance Research Database of Taiwan.
These three group subjects were matched by age, sex, comorbidity, and enrollment time in a 1 : 2 : 2 ratio.
The Cox proportional hazard regression models were used to identify the potential risk factors for lower gastrointestinal bleeding.
Results.
Dialysis CKD patients (n=574) had a higher incidence of lower GI bleeding than dialysis-free CKD patients (n=1148) and control subjects (n=1148) (12.9% vs.
3.6% and 2.8%; both P<0.001).
Multivariate analysis showed that extreme old age (age≥85), male gender, dialysis-free CKD, and dialysis CKD were independent factors of lower GI bleeding.
Additionally, dialysis CKD patients also had a higher incidence of angiodysplasia bleeding compared to dialysis-free CKD patients and control subjects (1.1% vs.
0.1% and 0.1%, respectively; both P=0.003).
Conclusion.
Hemodialysis may have higher risk of lower GI bleeding and angiodysplasia bleeding.
American Psychological Association (APA)
Tsai, Tzung-Jiun& Chen, Wen-Chih& Huang, Yu-Tung& Yang, Yi-Hsin& Feng, I-Che& Wu, Wen-Chieh…[et al.]. 2020. Hemodialysis Increases the Risk of Lower Gastrointestinal Bleeding and Angiodysplasia Bleeding: A Nationwide Population Study. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1166984
Modern Language Association (MLA)
Tsai, Tzung-Jiun…[et al.]. Hemodialysis Increases the Risk of Lower Gastrointestinal Bleeding and Angiodysplasia Bleeding: A Nationwide Population Study. Gastroenterology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1166984
American Medical Association (AMA)
Tsai, Tzung-Jiun& Chen, Wen-Chih& Huang, Yu-Tung& Yang, Yi-Hsin& Feng, I-Che& Wu, Wen-Chieh…[et al.]. Hemodialysis Increases the Risk of Lower Gastrointestinal Bleeding and Angiodysplasia Bleeding: A Nationwide Population Study. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1166984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166984