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Chromosome 1 Sequence Analysis of C57BL6J-Chr1KM Mouse Strain
Joint Authors
Xu, Fuyi
Chao, Tianzhu
Zhang, Yiyin
Hu, Shixian
Zhou, Yuxun
Xu, Hongyan
Xiao, Junhua
Li, Kai
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The Chinese Kunming (KM) mouse is a widely used outbred mouse stock in China.
However, its genetic structure remains unclear.
In this study, we sequenced the genome of the C57BL/6J-Chr1KM (B6-Chr1KM) strain, the chromosome 1 (Chr 1) of which was derived from one KM mouse.
With 36.6× average coverage of the entire genome, 0.48 million single nucleotide polymorphisms (SNPs) and 96,679 indels were detected on Chr 1 through comparison with reference strain C57BL/6J.
Moreover, 46,590 of them were classified as novel mutations.
Further functional annotation identified 155 genes harboring potentially functional variants, among which 27 genes have been associated with human diseases.
We then performed sequence similarity and Bayesian concordance analysis using the SNPs identified on Chr 1 and their counterparts in three subspecies, Mus musculus domesticus, M.
m.
musculus, and M.
m.
castaneus.
Both analyses suggested that the Chr 1 sequence of B6-Chr1KM was predominantly derived from M.
m.
domesticus while 9.7% of the sequence was found to be from M.
m.
musculus.
In conclusion, our analysis provided a detailed description of the genetic variations on Chr 1 of B6-Chr1KM and a new perspective on the subspecies origin of KM mouse which can be used to guide further genetic studies with this mouse strain.
American Psychological Association (APA)
Xu, Fuyi& Chao, Tianzhu& Zhang, Yiyin& Hu, Shixian& Zhou, Yuxun& Xu, Hongyan…[et al.]. 2017. Chromosome 1 Sequence Analysis of C57BL6J-Chr1KM Mouse Strain. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166987
Modern Language Association (MLA)
Xu, Fuyi…[et al.]. Chromosome 1 Sequence Analysis of C57BL6J-Chr1KM Mouse Strain. International Journal of Genomics No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166987
American Medical Association (AMA)
Xu, Fuyi& Chao, Tianzhu& Zhang, Yiyin& Hu, Shixian& Zhou, Yuxun& Xu, Hongyan…[et al.]. Chromosome 1 Sequence Analysis of C57BL6J-Chr1KM Mouse Strain. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166987