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Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis
Joint Authors
Starowicz, Katarzyna
Korostyński, Michał
Małek, Natalia
Piechota, Marcin
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Biomarkers of osteoarthritis (OA) that can accurately diagnose the disease at the earliest stage would significantly support efforts to develop treatments for prevention and early intervention.
We have sought to determine the time course of alterations in peripheral blood gene expression profile associated with the development of OA.
Blood samples were collected from a tail vein of individual rats with monosodium iodoacetate- (MIA-) induced OA (2, 14, 21, and 28 days after the treatment).
We used whole-genome microarrays to reveal OA-related transcriptional alterations of 72 transcripts.
Three main groups of coexpressed genes revealed diverse time-dependent profiles of up- and downregulation.
Functional links that connect expression of the gradually downregulated genes to the G13 signaling pathway were indicated.
The mRNA abundance levels of the identified transcripts were further analyzed in publicly available gene expression dataset obtained from a GARP study cohort of OA patients.
We revealed three-gene signature differentially expressed in both rat and human blood (TNK2, KCTD2, and WDR37).
The alterations in expression of the selected transcripts in peripheral blood samples of the patients indicate heterogeneity of the OA profiles potentially related to disease progress and severity of clinical symptoms.
Our study identifies several potential stage-specific biomarkers of OA progression.
American Psychological Association (APA)
Korostyński, Michał& Małek, Natalia& Piechota, Marcin& Starowicz, Katarzyna. 2017. Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166988
Modern Language Association (MLA)
Korostyński, Michał…[et al.]. Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis. International Journal of Genomics No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1166988
American Medical Association (AMA)
Korostyński, Michał& Małek, Natalia& Piechota, Marcin& Starowicz, Katarzyna. Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166988