Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location
Joint Authors
Cho, Kiho
Lee, Kang-Hoon
Lim, Debora
Greenhalgh, David
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Transposable repetitive elements, named the “TREome,” represent ~40% of the mouse genome.
We postulate that the germ line genome undergoes temporal and spatial diversification into somatic genomes in conjunction with the TREome activity.
C57BL/6J inbred mice were subjected to genomic landscape analyses using a TREome probe from murine leukemia virus-type endogenous retroviruses (MLV-ERVs).
None shared the same MLV-ERV landscape within each comparison group: (1) sperm and 18 tissues from one mouse, (2) six brain compartments from two females, (3) spleen and thymus samples from four age groups, (4) three spatial tissue sets from two females, and (5) kidney and liver samples from three females and three males.
Interestingly, males had more genomic MLV-ERV copies than females; moreover, only in the males, the kidneys had higher MLV-ERV copies than the livers.
Perhaps, the mouse-, gender-, and tissue/cell-dependent MLV-ERV landscapes are linked to the individual-specific and dynamic phenotypes of the C57BL/6J inbred population.
American Psychological Association (APA)
Lee, Kang-Hoon& Lim, Debora& Greenhalgh, David& Cho, Kiho. 2017. Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1167044
Modern Language Association (MLA)
Lee, Kang-Hoon…[et al.]. Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location. International Journal of Genomics No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1167044
American Medical Association (AMA)
Lee, Kang-Hoon& Lim, Debora& Greenhalgh, David& Cho, Kiho. Highly Variable Genomic Landscape of Endogenous Retroviruses in the C57BL6J Inbred Strain, Depending on Individual Mouse, Gender, Organ Type, and Organ Location. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1167044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167044