A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis
Joint Authors
Wen, Zhining
Li, Menglong
Xue, Jiwei
Xie, Fanfan
Xu, Junmei
Liu, Yuan
Liang, Yu
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
MicroRNA (miRNA) plays an important role in the degradation and inhibition of mRNAs and is a kind of essential drug targets for cancer therapy.
To facilitate the clinical cancer research, we proposed a network-based strategy to identify the cancer-related miRNAs and to predict their targeted genes based on the gene expression profiles.
The strategy was validated by using the data sets of acute myeloid leukemia (AML), breast invasive carcinoma (BRCA), and kidney renal clear cell carcinoma (KIRC).
The results showed that in the top 20 miRNAs ranked by their degrees, 90.0% (18/20), 70.0% (14/20), and 70.0% (14/20) miRNAs were found to be associated with the cancers for AML, BRCA, and KIRC, respectively.
The KEGG pathways and GO terms enriched with the genes that were predicted as the targets of the cancer-related miRNAs were significantly associated with the biological processes of cancers.
In addition, several genes, which were predicted to be regulated by more than three miRNAs, were identified to be the potential drug targets annotated by using the human protein atlas database.
Our results demonstrated that the proposed strategy can be helpful for predicting the miRNA-mRNA interactions in tumorigenesis and identifying the cancer-related miRNAs as the potential drug targets.
American Psychological Association (APA)
Xue, Jiwei& Xie, Fanfan& Xu, Junmei& Liu, Yuan& Liang, Yu& Wen, Zhining…[et al.]. 2017. A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1167047
Modern Language Association (MLA)
Xue, Jiwei…[et al.]. A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis. International Journal of Genomics No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1167047
American Medical Association (AMA)
Xue, Jiwei& Xie, Fanfan& Xu, Junmei& Liu, Yuan& Liang, Yu& Wen, Zhining…[et al.]. A New Network-Based Strategy for Predicting the Potential miRNA-mRNA Interactions in Tumorigenesis. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1167047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167047