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The Prevalence and Determinants of Hepatic Steatosis Assessed by Controlled Attenuation Parameter in Thai Chronic Hepatitis C Patients
Joint Authors
Sirinawasatien, A.
Techasirioangkun, T.
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
To describe the prevalence of hepatic steatosis using a controlled attenuation parameter (CAP) and to identify the determinants associated with steatosis in Thai chronic hepatitis C patients.
Patients and Methods.
An observational study was conducted among consecutive chronic hepatitis C patients who underwent vibration-controlled transient elastography (VCTE, FibroScan®) with CAP and followed up at Rajavithi Hospital, Bangkok, Thailand, between June 2018 and May 2019.
Hepatic steatosis (i.e., steatosis grades S1-3) was defined by the CAP cutoff value of ≥248 (dB/m).
VCTE with CAP assessments and medical records were retrospectively reviewed, and the prevalence and determinants of hepatic steatosis were analyzed.
Results.
A total of 197 eligible patients, of whom 127 (64.5%) were male, were included.
The mean age was 54.52 years (SD 9.49 years), and 41.1% of subjects had a body mass index≥25.
The prevalence of hepatic steatosis was 26.9%.
The mean liver stiffness measurement (LSM) was 21.50 kPa (SD 15.58 kPa), and 61.9% of the study population had cirrhosis, which was defined as LSM≥12.5 kPa.
Genotype (GT) 3 was predominant at 40.1%, followed by GT1 at 38.1% and GT6 at 21.8%.
The median serum hepatitis C virus viral load was 1,100,000 IU/mL (range 5,824-20,436,840).
The significant determinants of hepatic steatosis were obesity (aOR 8.58 (95% CI: 3.41-21.54)) and diabetes mellitus (aOR 3.30 (95% CI: 1.24-8.78)).
Conclusion.
A large proportion of these Thai chronic hepatitis C patients (26.9%) had hepatic steatosis, which was strongly associated with host metabolic factors, e.g., obesity (BMI≥25) and diabetes mellitus.
These cofactors contributed to the progression of liver disease to cirrhosis and required concurrent management with antiviral therapy.
American Psychological Association (APA)
Sirinawasatien, A.& Techasirioangkun, T.. 2020. The Prevalence and Determinants of Hepatic Steatosis Assessed by Controlled Attenuation Parameter in Thai Chronic Hepatitis C Patients. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167074
Modern Language Association (MLA)
Sirinawasatien, A.& Techasirioangkun, T.. The Prevalence and Determinants of Hepatic Steatosis Assessed by Controlled Attenuation Parameter in Thai Chronic Hepatitis C Patients. Gastroenterology Research and Practice No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1167074
American Medical Association (AMA)
Sirinawasatien, A.& Techasirioangkun, T.. The Prevalence and Determinants of Hepatic Steatosis Assessed by Controlled Attenuation Parameter in Thai Chronic Hepatitis C Patients. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167074