The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach
Joint Authors
Espinal-Enríquez, Jesús
González-Terán, Daniel
Hernández-Lemus, Enrique
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Understanding the general principles underlying genetic regulation in eukaryotes is an incomplete and challenging endeavor.
The lack of experimental information regarding the regulation of the whole set of transcription factors and their targets in different cell types is one of the main reasons to this incompleteness.
So far, there is a small set of curated known interactions between transcription factors and their downstream genes.
Here, we built a transcription factor network for human monocytic THP-1 myeloid cells based on the experimentally curated FANTOM4 database where nodes are genes and the experimental interactions correspond to links.
We present the topological parameters which define the network as well as some global structural features and introduce a relative inuence parameter to quantify the relevance of a transcription factor in the context of induction of a phenotype.
Genes like ZHX2, ADNP, or SMAD6 seem to be highly regulated to avoid an avalanche transcription event.
We compare these results with those of RegulonDB, a highly curated transcriptional network for the prokaryotic organism E.
coli, finding similarities between general hallmarks on both transcriptional programs.
We believe that an approach, such as the one shown here, could help to understand the one regulation of transcription in eukaryotic cells.
American Psychological Association (APA)
Espinal-Enríquez, Jesús& González-Terán, Daniel& Hernández-Lemus, Enrique. 2017. The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1167075
Modern Language Association (MLA)
Espinal-Enríquez, Jesús…[et al.]. The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach. International Journal of Genomics No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1167075
American Medical Association (AMA)
Espinal-Enríquez, Jesús& González-Terán, Daniel& Hernández-Lemus, Enrique. The Transcriptional Network Structure of a Myeloid Cell: A Computational Approach. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1167075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167075