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Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas
Joint Authors
Kim, Jaegil
Park, Woo-Jae
Jeong, Kwang-Joon
Kang, Sun Hee
Kim, Shin
Park, Jong-Wook
Kwon, Sun Young
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aberrant regulation of microRNA (miRNA) machinery components is associated with various human cancers, including papillary thyroid carcinoma (PTC), which is the most common type of thyroid cancer, and a higher prevalent female malignancy.
The purpose of this study is to investigate racial differences in mRNA expression levels of four miRNA machinery components, Dicer, Drosha, DGCR8, and AGO2, and their correlations with clinicopathological characteristics.
Forty PTC samples from female Asian Korean PTC patients were enrolled.
Using qPCR, we examined mRNA expression levels of the components and next validated our results by comparison with results of female white American in the TCGA PTC project.
Interestingly, mRNA expression levels of the selected factors were altered in the TCGA PTC samples.
However, only Drosha showed a significantly lower expression level in Asian Korean PTC samples.
Furthermore, the mRNA expression levels of the four components showed no association with clinicopathological characteristics in both groups.
On the other hand, positive correlations were observed between altered mRNA expression levels of Dicer and Drosha and DGCR8 and Drosha in TCGA PTC samples.
These findings collectively revealed that altered mRNA expression levels of miRNA machinery components might be responsible for racial differences in the carcinogenesis of PTC.
American Psychological Association (APA)
Kim, Jaegil& Park, Woo-Jae& Jeong, Kwang-Joon& Kang, Sun Hee& Kwon, Sun Young& Kim, Shin…[et al.]. 2017. Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1167134
Modern Language Association (MLA)
Kim, Jaegil…[et al.]. Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas. International Journal of Genomics No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1167134
American Medical Association (AMA)
Kim, Jaegil& Park, Woo-Jae& Jeong, Kwang-Joon& Kang, Sun Hee& Kwon, Sun Young& Kim, Shin…[et al.]. Racial Differences in Expression Levels of miRNA Machinery-Related Genes, Dicer, Drosha, DGCR8, and AGO2, in Asian Korean Papillary Thyroid Carcinoma and Comparative Validation Using the Cancer Genome Atlas. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1167134
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167134