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A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1CCDC170 Locus Is Associated with Bone Mineral Density
Joint Authors
Ibarra-Cortés, Bertha
Villalobos-Comparán, Marisela
Jiménez-Ortega, Rogelio F.
Estrada, Karol
Parra-Torres, Alma Y.
González-Mercado, Anahí
Patiño, Nelly
Castillejos-López, Manuel
Quiterio, Manuel
Fernandez-López, Juan Carlos
Romero-Hidalgo, Sandra
Salmerón, Jorge
Velázquez-Cruz, Rafael
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
To identify genetic variants influencing bone mineral density (BMD) in the Mexican-Mestizo population, we performed a GWAS for femoral neck (FN) and lumbar spine (LS) in Mexican-Mestizo postmenopausal women.
In the discovery sample, 300,000 SNPs were genotyped in a cohort of 411 postmenopausal women and seven SNPs were analyzed in the replication cohort (n=420).
The combined results of a meta-analysis from the discovery and replication samples identified two loci, RMND1 (rs6904364, P=2.77×10−4) and CCDC170 (rs17081341, P=1.62×10−5), associated with FN BMD.
We also compared our results with those of the Genetic Factors for Osteoporosis (GEFOS) Consortium meta-analysis.
The comparison revealed two loci previously reported in the GEFOS meta-analysis: SOX6 (rs7128738) and PKDCC (rs11887431) associated with FN and LS BMD, respectively, in our study population.
Interestingly, rs17081341 rare in Caucasians (minor allele frequency < 0.03) was found in high frequency in our population, which suggests that this association could be specific to non-Caucasian populations.
In conclusion, the first pilot Mexican GWA study of BMD confirmed previously identified loci and also demonstrated the importance of studying variability in diverse populations and/or specific populations.
American Psychological Association (APA)
Villalobos-Comparán, Marisela& Jiménez-Ortega, Rogelio F.& Estrada, Karol& Parra-Torres, Alma Y.& González-Mercado, Anahí& Patiño, Nelly…[et al.]. 2017. A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1CCDC170 Locus Is Associated with Bone Mineral Density. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167147
Modern Language Association (MLA)
Villalobos-Comparán, Marisela…[et al.]. A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1CCDC170 Locus Is Associated with Bone Mineral Density. International Journal of Genomics No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1167147
American Medical Association (AMA)
Villalobos-Comparán, Marisela& Jiménez-Ortega, Rogelio F.& Estrada, Karol& Parra-Torres, Alma Y.& González-Mercado, Anahí& Patiño, Nelly…[et al.]. A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1CCDC170 Locus Is Associated with Bone Mineral Density. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167147