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Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers
Joint Authors
Glavač, Damjan
Bolha, Luka
Ravnik-Glavač, Metka
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-04
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that form covalently closed continuous loop structures, lacking the terminal 5′ and 3′ ends.
CircRNAs are generated in the process of back-splicing and can originate from different genomic regions.
Their unique circular structure makes circRNAs more stable than linear RNAs.
In addition, they also display insensitivity to ribonuclease activity.
Generally, circRNAs function as microRNA (miRNA) sponges and have a regulatory role in transcription and translation.
They may be also translated in a cap-independent manner in vivo, to generate specific proteins.
In the last decade, next-generation sequencing techniques, especially RNA-seq, have revealed great abundance and also dysregulation of many circRNAs in various diseases, suggesting their involvement in disease development and progression.
Regarding their high stability and relatively specific differential expression patterns in tissues and extracellular environment (e.g., body fluids), they are regarded as promising novel biomarkers in cancer.
Therefore, we focus this review on describing circRNA biogenesis, function, and involvement in human cancer development and address the potential of circRNAs to be effectively used as novel cancer diagnostic and prognostic biomarkers.
American Psychological Association (APA)
Bolha, Luka& Ravnik-Glavač, Metka& Glavač, Damjan. 2017. Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1167170
Modern Language Association (MLA)
Bolha, Luka…[et al.]. Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers. International Journal of Genomics No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1167170
American Medical Association (AMA)
Bolha, Luka& Ravnik-Glavač, Metka& Glavač, Damjan. Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1167170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167170