Synthesis of New Oxindoles and Determination of Their Antibacterial Properties
Joint Authors
Abonia, Rodrigo
Romo, Pablo E.
Insuasty, Braulio
Crespo, María del Pilar
Quiroga, Jairo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A versatile method for the synthesis of new oxindoles was developed by the reaction between substituted isatins and 5-aminopyrazoles.
The reaction was carried out at room temperature in ethanol using p-toluenesulfonic acid as the catalyst.
The products were obtained with acceptable to excellent yields (44–96%).
Structures of the new compounds were unambiguously established by spectroscopic and analytical techniques.
The antibacterial activity was determined by microdilution assays.
Compounds 3b, 3e, and 3g showed antistaphylococcal activity, particularly compound 3e displayed a potent activity against the vancomycin intermediate Staphylococcus aureus (VISA).
Compounds 3i, 3j, and 3o inhibited Neisseria gonorrhoeae growth.
American Psychological Association (APA)
Romo, Pablo E.& Insuasty, Braulio& Abonia, Rodrigo& Crespo, María del Pilar& Quiroga, Jairo. 2020. Synthesis of New Oxindoles and Determination of Their Antibacterial Properties. Heteroatom Chemistry،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1167220
Modern Language Association (MLA)
Romo, Pablo E.…[et al.]. Synthesis of New Oxindoles and Determination of Their Antibacterial Properties. Heteroatom Chemistry No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1167220
American Medical Association (AMA)
Romo, Pablo E.& Insuasty, Braulio& Abonia, Rodrigo& Crespo, María del Pilar& Quiroga, Jairo. Synthesis of New Oxindoles and Determination of Their Antibacterial Properties. Heteroatom Chemistry. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1167220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167220