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MicroRNA in Glioblastoma: An Overview
Joint Authors
Romani, Massimo
Pistillo, Maria Pia
Banelli, Barbara
Forlani, Alessandra
Allemanni, Giorgio
Morabito, Anna
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-06
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Glioblastoma is the most aggressive brain tumor and, even with the current multimodal therapy, is an invariably lethal cancer with a life expectancy that depends on the tumor subtype but, even in the most favorable cases, rarely exceeds 2 years.
Epigenetic factors play an important role in gliomagenesis, are strong predictors of outcome, and are important determinants for the resistance to radio- and chemotherapy.
The latest addition to the epigenetic machinery is the noncoding RNA (ncRNA), that is, RNA molecules that are not translated into a protein and that exert their function by base pairing with other nucleic acids in a reversible and nonmutational mode.
MicroRNAs (miRNA) are a class of ncRNA of about 22 bp that regulate gene expression by binding to complementary sequences in the mRNA and silence its translation into proteins.
MicroRNAs reversibly regulate transcription through nonmutational mechanisms; accordingly, they can be considered as epigenetic effectors.
In this review, we will discuss the role of miRNA in glioma focusing on their role in drug resistance and on their potential applications in the therapy of this tumor.
American Psychological Association (APA)
Banelli, Barbara& Forlani, Alessandra& Allemanni, Giorgio& Morabito, Anna& Pistillo, Maria Pia& Romani, Massimo. 2017. MicroRNA in Glioblastoma: An Overview. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1167235
Modern Language Association (MLA)
Banelli, Barbara…[et al.]. MicroRNA in Glioblastoma: An Overview. International Journal of Genomics No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1167235
American Medical Association (AMA)
Banelli, Barbara& Forlani, Alessandra& Allemanni, Giorgio& Morabito, Anna& Pistillo, Maria Pia& Romani, Massimo. MicroRNA in Glioblastoma: An Overview. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1167235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167235