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Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses
Joint Authors
Izzo, Antonella
Manco, Rosanna
Cristofaro, Tiziana de
Bonfiglio, Ferdinando
Cicatiello, Rita
Mollo, Nunzia
Martino, Marco De
Genesio, Rita
Zannini, Mariastella
Conti, Anna
Nitsch, Lucio
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Dosage-dependent upregulation of most of chromosome 21 (Hsa21) genes has been demonstrated in heart tissues of fetuses with Down syndrome (DS).
Also miRNAs might play important roles in the cardiac phenotype as they are highly expressed in the heart and regulate cardiac development.
Five Hsa21 miRNAs have been well studied in the past: miR-99a-5p, miR-125b-2-5p, let-7c-5p, miR-155-5p, and miR-802-5p but few information is available about their expression in trisomic tissues.
In this study, we evaluated the expression of these miRNAs in heart tissues from DS fetuses, showing that miR-99a-5p, miR-155-5p, and let-7c-5p were overexpressed in trisomic hearts.
To investigate their role, predicted targets were obtained from different databases and cross-validated using the gene expression profiling dataset we previously generated for fetal hearts.
Eighty-five targets of let-7c-5p, 33 of miR-155-5p, and 10 of miR-99a-5p were expressed in fetal heart and downregulated in trisomic hearts.
As nuclear encoded mitochondrial genes were found downregulated in trisomic hearts and mitochondrial dysfunction is a hallmark of DS phenotypes, we put special attention to let-7c-5p and miR-155-5p targets downregulated in DS fetal hearts and involved in mitochondrial function.
The let-7c-5p predicted target SLC25A4/ANT1 was identified as a possible candidate for both mitochondrial and cardiac anomalies.
American Psychological Association (APA)
Izzo, Antonella& Manco, Rosanna& Cristofaro, Tiziana de& Bonfiglio, Ferdinando& Cicatiello, Rita& Mollo, Nunzia…[et al.]. 2017. Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1167257
Modern Language Association (MLA)
Izzo, Antonella…[et al.]. Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses. International Journal of Genomics No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1167257
American Medical Association (AMA)
Izzo, Antonella& Manco, Rosanna& Cristofaro, Tiziana de& Bonfiglio, Ferdinando& Cicatiello, Rita& Mollo, Nunzia…[et al.]. Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1167257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167257