Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis
Joint Authors
Ye, Hanhui
Yuan, Jinjin
Liu, Xiaolong
Han, Xiao
Chen, Yahong
Han, Xianlin
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Acquired immune deficiency syndrome is a severe disease in humans caused by human immunodeficiency virus.
Several human genes were characterized as host genetic factors that impact the processes of AIDS disease.
Recent studies on AIDS patients revealed a series disease is complicating with AIDS.
To resolve gene interaction between AIDS and complicating diseases, a canonical correlation analysis was used to identify the global correlation between AIDS and other disease pathway genes expression.
The results showed that HLA-B, HLA-A, MH9, ZNED1, IRF1, TLR8, TSG101, NCOR2, and GML are the key AIDS-restricted genes highly correlated with other disease pathway genes.
Furthermore, pathway genes in several diseases such as asthma, autoimmune thyroid disease, and malaria were globally correlated with ARGs.
It suggests that these diseases are a high risk in AIDS patients as complicating diseases.
American Psychological Association (APA)
Chen, Yahong& Yuan, Jinjin& Han, Xianlin& Liu, Xiaolong& Han, Xiao& Ye, Hanhui. 2017. Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1167266
Modern Language Association (MLA)
Chen, Yahong…[et al.]. Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis. International Journal of Genomics No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1167266
American Medical Association (AMA)
Chen, Yahong& Yuan, Jinjin& Han, Xianlin& Liu, Xiaolong& Han, Xiao& Ye, Hanhui. Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1167266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167266