Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches
Joint Authors
Li, Dong
Li, Aixin
Zhou, Hairui
Wang, Xi
Li, Peng
Bi, Sheng
Teng, Yang
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Drug-induced myopathy (DIM) is a rare side effect; however, the consequence could be fatal.
There are few reports to systematically assess the underlying mechanism of DIM.
In this study, we curated the comprehensive DIM drug list based on structured labeling products (SPLs) and carried out the analysis based on chemical structure space, drug protein interaction, side effect space, and transcriptomic profiling space.
Some key features are enriched from each of analysis.
Specifically, the similarity of DIM drugs is more significant than random chance, which shows that the chemical structure could distinguish the DIM-positive drugs from negatives.
The cytochrome P450 (CYP) was identified to be shared by DIM drugs, which indicated the important role of metabolism in DIM.
Three pathways including pathways in cancer, MAPK signaling pathway, and GnRH signaling pathway enriched based on transcriptomic analysis may explain the underlying mechanism of DIM.
Although the DIM is the current focus of the study, the proposed approaches could be applied to other toxicity assessments and facilitate the safety evaluation.
American Psychological Association (APA)
Li, Dong& Li, Aixin& Zhou, Hairui& Wang, Xi& Li, Peng& Bi, Sheng…[et al.]. 2017. Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1167269
Modern Language Association (MLA)
Li, Dong…[et al.]. Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches. International Journal of Genomics No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1167269
American Medical Association (AMA)
Li, Dong& Li, Aixin& Zhou, Hairui& Wang, Xi& Li, Peng& Bi, Sheng…[et al.]. Uncover the Underlying Mechanism of Drug-Induced Myopathy by Using Systems Biology Approaches. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1167269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167269