Efficacy of NucleotideNucleoside Analogues and Hepatitis B Immunoglobulin Therapy in Blocking Mother-to-Child Transmission of Hepatitis B in an Eastern Chinese Group
Joint Authors
Wang, Chengwei
Sun, Xiaojun
Wang, Bian
Yang, Xiuzhen
Xu, Hongtao
Shen, Meilong
Zhu, Kuichun
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-17
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The objective of this study was to investigate the efficacy and potential side-effects of nucleotide/nucleoside analogues and hepatitis B immunoglobulin injection of newborns in blocking mother-to-child transmission of hepatitis B virus in the middle and late pregnancy period.
238 cases of enrolled pregnant women were divided into the Telbivudine group, the Tenofovir group, the Lamivudine group, and the hepatitis B immunoglobulin (HBIG) group.
Enrolled patients received corresponding therapies.
Clinical and laboratory data were collected.
Results showed that the levels of HBV DNA of the enrolled pregnant women in the Telbivudine, Tenofovir, and Lamivudine groups decreased rapidly after 12 weeks of drug intervention compared with those in the control.
HBsAg positive rate in newborns and in children 24 weeks after birth was 0/60, 0/60, 0/60, 3/30, and 11/28 in the Telbivudine, Tenofovir, Lamivudine, HBIG, and control groups, respectively.
No significant side-effects were identified after following up to 12 months after birth.
Our results show that routine HBV vaccine plus HBIG injections is insufficient in blocking mother-to-child HBV transmission.
Administration of nucleotide/nucleoside analogues or HBIG at pregnancy is suggested to maximize the blocking of vertical HBV transmission.
American Psychological Association (APA)
Sun, Xiaojun& Wang, Chengwei& Wang, Bian& Yang, Xiuzhen& Xu, Hongtao& Shen, Meilong…[et al.]. 2020. Efficacy of NucleotideNucleoside Analogues and Hepatitis B Immunoglobulin Therapy in Blocking Mother-to-Child Transmission of Hepatitis B in an Eastern Chinese Group. Infectious Diseases in Obstetrics and Gynecology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1167271
Modern Language Association (MLA)
Sun, Xiaojun…[et al.]. Efficacy of NucleotideNucleoside Analogues and Hepatitis B Immunoglobulin Therapy in Blocking Mother-to-Child Transmission of Hepatitis B in an Eastern Chinese Group. Infectious Diseases in Obstetrics and Gynecology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1167271
American Medical Association (AMA)
Sun, Xiaojun& Wang, Chengwei& Wang, Bian& Yang, Xiuzhen& Xu, Hongtao& Shen, Meilong…[et al.]. Efficacy of NucleotideNucleoside Analogues and Hepatitis B Immunoglobulin Therapy in Blocking Mother-to-Child Transmission of Hepatitis B in an Eastern Chinese Group. Infectious Diseases in Obstetrics and Gynecology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1167271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167271