Shorter Leukocyte Telomere Length in Relation to Presumed Nonalcoholic Fatty Liver Disease in Mexican-American Men in NHANES 1999–2002
Joint Authors
Epel, Elissa S.
Rehkopf, David
Rosenthal, Philip
Wojcicki, Janet M.
Source
International Journal of Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Leukocyte telomere length is shorter in response to chronic disease processes associated with inflammation such as diabetes mellitus and coronary artery disease.
Data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2002 was used to explore the relationship between leukocyte telomere length and presumed NAFLD, as indicated by elevated serum alanine aminotransferase (ALT) levels, obesity, or abdominal obesity.
Logistic regression models were used to evaluate the relationship between telomere length and presumed markers of NAFLD adjusting for possible confounders.
There was no relationship between elevated ALT levels, abdominal obesity, or obesity and telomere length in adjusted models in NHANES (OR 1.13, 95% CI 0.48–2.65; OR 1.17, 95% CI 0.52–2.62, resp.).
Mexican-American men had shorter telomere length in relation to presumed NAFLD (OR 0.07, 95% CI 0.006–0.79) and using different indicators of NAFLD (OR 0.012, 95% CI 0.0006–0.24).
Mexican origin with presumed NAFLD had shorter telomere length than men in other population groups.
Longitudinal studies are necessary to evaluate the role of telomere length as a potential predictor to assess pathogenesis of NALFD in Mexicans.
American Psychological Association (APA)
Wojcicki, Janet M.& Rehkopf, David& Epel, Elissa S.& Rosenthal, Philip. 2017. Shorter Leukocyte Telomere Length in Relation to Presumed Nonalcoholic Fatty Liver Disease in Mexican-American Men in NHANES 1999–2002. International Journal of Hepatology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1167333
Modern Language Association (MLA)
Wojcicki, Janet M.…[et al.]. Shorter Leukocyte Telomere Length in Relation to Presumed Nonalcoholic Fatty Liver Disease in Mexican-American Men in NHANES 1999–2002. International Journal of Hepatology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1167333
American Medical Association (AMA)
Wojcicki, Janet M.& Rehkopf, David& Epel, Elissa S.& Rosenthal, Philip. Shorter Leukocyte Telomere Length in Relation to Presumed Nonalcoholic Fatty Liver Disease in Mexican-American Men in NHANES 1999–2002. International Journal of Hepatology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1167333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167333