Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease
Joint Authors
Kobtan, Abdelrahman
Abd-Elsalam, Sherief
Mansour, Loai
Yousef, Mohamed
Ahmed, Sameh Abdelkhalik
Selim, Amal
Hawash, Nehad
Tawfik, Ahmed Khaled
Badawi, Rehab
Elnawasany, Sally
Elkhouly, Reham Abdelkader
Hanafy, Amr Shaaban
Rizk, Fatma H.
Source
International Journal of Hepatology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
We aimed to investigate the safety and efficacy of propofol plus fentanyl versus midazolam plus fentanyl as sedative for patients with advanced liver disease presented for gastrointestinal endoscopy.
Methods.
A total of 100 patients with liver cirrhosis referred for upper endoscopy were enrolled and divided equally in two groups, midazolam plus fentanyl group and propofol plus fentanyl group.
All patients were subjected to history taking, estimation of level of sedation, endoscopist rating, and hemodynamic parameters including oxygen saturation, heart rate, mean arterial pressure, incidence of side effect as (bradycardia, hypotension, hypoxia, nausea and vomiting, cough, shivering, or diplopia), time needed for complete recovery, and time needed for discharge.
Results.
There was no statistical significant difference between the studied groups regarding age, sex, weight, Child–Pugh classification score, type and duration of endoscopic intervention, time needed for complete recovery, or time needed for discharge.
Complication rates were similar in both groups except for mean arterial blood pressure which was significantly lower in group of patients receiving propofol and fentanyl (P=0.001).
Conclusion.
The use of either propofol or midazolam in combination to fentanyl is effective in sedation of patients with advanced liver diseases presented for upper GIT endoscope.
The trial is registered with ClinicalTrials.gov Identifier: NCT03063866.
American Psychological Association (APA)
Ahmed, Sameh Abdelkhalik& Selim, Amal& Hawash, Nehad& Tawfik, Ahmed Khaled& Yousef, Mohamed& Kobtan, Abdelrahman…[et al.]. 2017. Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease. International Journal of Hepatology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1167338
Modern Language Association (MLA)
Ahmed, Sameh Abdelkhalik…[et al.]. Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease. International Journal of Hepatology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1167338
American Medical Association (AMA)
Ahmed, Sameh Abdelkhalik& Selim, Amal& Hawash, Nehad& Tawfik, Ahmed Khaled& Yousef, Mohamed& Kobtan, Abdelrahman…[et al.]. Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease. International Journal of Hepatology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1167338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167338