Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect
Joint Authors
Nakamura, Takuto
Yamazato, Masanobu
Ishida, Akio
Ohya, Yusuke
Source
International Journal of Hypertension
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aminopeptidase A (APA) cleaves angiotensin (Ang) II, kallidin, and other related peptides.
In the brain, it activates the renin angiotensin system and causes hypertension.
Limited data are available on the dipsogenic effect of APA and pressor effect of degraded peptides of APA such as bradykinin.
Wistar-Kyoto rats received intracerebroventricular (icv) APA in a conscious, unrestrained state after pretreatment with (i) vehicle, (ii) 80 μg of telmisartan, an Ang II type-1 (AT1) receptor blocker, (iii) 800 nmol of amastatin, an aminopeptidase inhibitor, and (iv) 1 nmol of HOE-140, a bradykinin B2 receptor blocker.
Icv administration of 400 and 800 ng of APA increased blood pressure by 12.6 ± 3.0 and 19.0 ± 3.1 mmHg, respectively.
APA did not evoke drinking behavior.
Pressor response to APA was attenuated on pretreatment with telmisartan (vehicle: 22.1 ± 2.2 mmHg versus telmisartan: 10.4 ± 3.2 mmHg).
Pressor response to APA was also attenuated with amastatin and HOE-140 (vehicle: 26.5 ± 1.1 mmHg, amastatin: 14.4 ± 4.2 mmHg, HOE-140: 16.4 ± 2.2 mmHg).
In conclusion, APA increase in the brain evokes a pressor response via enzymatic activity without dipsogenic effect.
AT1 receptors and B2 receptors in the brain may contribute to the APA-induced pressor response.
American Psychological Association (APA)
Nakamura, Takuto& Yamazato, Masanobu& Ishida, Akio& Ohya, Yusuke. 2017. Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect. International Journal of Hypertension،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167370
Modern Language Association (MLA)
Nakamura, Takuto…[et al.]. Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect. International Journal of Hypertension No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1167370
American Medical Association (AMA)
Nakamura, Takuto& Yamazato, Masanobu& Ishida, Akio& Ohya, Yusuke. Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect. International Journal of Hypertension. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1167370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167370