The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis
Joint Authors
Yaroustovsky, Michael
Rogalskaya, Ekaterina
Plyushch, Marina
Klimovich, Ludmila
Samsonova, Nataliya
Abramyan, Marina
Source
International Journal of Inflammation
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
To analyse the clinical informativity of the neutrophil oxidative response level (“Response”) during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications.
Methods.
Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128).
The composite of laboratory studies included CRP, PCT, EAA with “Response” level, and presepsin.
Results.
83% of patients had a “normal” neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response.
Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p<0.05).
Conclusions.
EAA results should be interpreted with the level of neutrophil response.
“Response” > 0.5 has a negative predictive value; the EAA < 0.6 at “Response” < 0.5 may indicate a high level of endotoxaemia.
American Psychological Association (APA)
Yaroustovsky, Michael& Rogalskaya, Ekaterina& Plyushch, Marina& Klimovich, Ludmila& Samsonova, Nataliya& Abramyan, Marina. 2017. The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis. International Journal of Inflammation،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1167441
Modern Language Association (MLA)
Yaroustovsky, Michael…[et al.]. The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis. International Journal of Inflammation No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1167441
American Medical Association (AMA)
Yaroustovsky, Michael& Rogalskaya, Ekaterina& Plyushch, Marina& Klimovich, Ludmila& Samsonova, Nataliya& Abramyan, Marina. The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis. International Journal of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1167441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167441