Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1
Joint Authors
Li, Jian-Dong
Konduru, Anuhya Sharma
Matsuyama, Shingo
Lee, Byung-Cheol
Komatsu, Kensei
Source
International Journal of Inflammation
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Otitis media (OM), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection.
Nontypeable Haemophilus influenzae (NTHi) pathogen is responsible for approximately one-third of episodes of bacteria-caused OM.
Current treatments for bacterial OM rely on the systemic use of antibiotics, which often leads to the emergence of multidrug resistant bacterial strains.
Therefore there is an urgent need for developing alternative therapies strategies for controlling mucus overproduction in OM.
MUC5AC mucin has been shown to play a critical role in the pathogenesis of OM.
Here we show that curcumin derived from Curcuma longa plant is a potent inhibitor of NTHi-induced MUC5AC mucin expression in middle ear epithelial cells.
Curcumin inhibited MUC5AC expression by suppressing activation of p38 MAPK by upregulating MAPK phosphatase MKP-1.
Thus, our study identified curcumin as a potential therapeutic for inhibiting mucin overproduction in OM by upregulating MKP-1, a known negative regulator of inflammation.
American Psychological Association (APA)
Konduru, Anuhya Sharma& Matsuyama, Shingo& Lee, Byung-Cheol& Komatsu, Kensei& Li, Jian-Dong. 2017. Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1. International Journal of Inflammation،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167449
Modern Language Association (MLA)
Konduru, Anuhya Sharma…[et al.]. Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1. International Journal of Inflammation No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1167449
American Medical Association (AMA)
Konduru, Anuhya Sharma& Matsuyama, Shingo& Lee, Byung-Cheol& Komatsu, Kensei& Li, Jian-Dong. Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1. International Journal of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167449